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Medical Subject Headings
Last uploaded:
March 22, 2026
| Id | http://purl.bioontology.org/ontology/MESH/D053764
http://purl.bioontology.org/ontology/MESH/D053764
|
|---|---|
| Preferred Name | Presenilin-1 |
| Definitions |
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.
|
| Synonyms |
Presenilin 1
S182 Protein
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans. |
|---|---|
| altLabel |
Presenilin 1
S182 Protein
|
| prefLabel | Presenilin-1
|
| Machine permutation | 2007; was indexed under MEMBRANE PROTEINS 1995-2006
|
| HN | 2007
|
| Mapped from | |
| type | |
| tui |
T116
T123
|
| TERMUI |
T408355
T278676
T418310
|
| TH | NLM (2007)
|
| MMR | 20100625
|
| notation | D053764
|
| Semantic type UMLS property | |
| Inverse of AQ |
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|
| DX | 20070101
|
| cui | C0299212
|
| DC | 1
|
| MN | D12.776.543.696.500
|
| AQL | AD AE AG AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
|
| Inverse of RB | 0
|
| MDA | 20000706
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |