Medical Subject Headings

Last uploaded: January 16, 2025

Id	http://purl.bioontology.org/ontology/MESH/D053181 http://purl.bioontology.org/ontology/MESH/D053181
Preferred Name	Caspase 8
Definitions	A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.
Synonyms	Mch5 Protease CAP4 Protease FLICE Protein Pro Caspase 8 MACH Protein Procaspase 8 Pro-Caspase-8 Procaspase-8 Caspase-8
Type	http://www.w3.org/2002/07/owl#Class

definition	A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.
altLabel	Mch5 Protease CAP4 Protease FLICE Protein Pro Caspase 8 MACH Protein Procaspase 8 Pro-Caspase-8 Procaspase-8 Caspase-8 See more See less
prefLabel	Caspase 8
TH	NLM (2007)
notation	D053181
EC	antagonists & inhibitors:Caspase Inhibitors deficiency:Alstrom Syndrome
DX	20070101
Machine permutation	2007; CASPASE 8 was indexed under CASPASES 1999-2006 & under CYSTEINE PROTEINASES 1997-1998
MN	D12.776.476.024.320.025 D08.811.277.656.300.200.126.550.800 D08.811.277.656.262.500.126.550.800 D12.776.157.057.018.037 D12.776.476.075.421.037 D12.776.476.075.405.550.800 See more See less
FX	D056735
MMR	20210628
Mapped from	http://purl.bioontology.org/ontology/MESH/C505526 http://purl.bioontology.org/ontology/MESH/C505528 http://purl.bioontology.org/ontology/MESH/C505530
AQL	AD AE AN BI BL CF CH CL CS DE EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
HN	2007(2000)
subClassOf	http://purl.bioontology.org/ontology/MESH/D053418 http://purl.bioontology.org/ontology/MESH/D053471
Semantic type UMLS property	http://purl.bioontology.org/ontology/STY/T126 http://purl.bioontology.org/ontology/STY/T116
Inverse of RB	EC 3.4.22.- 0
DC	1
MDA	20060705
Inverse of RO	http://purl.bioontology.org/ontology/MESH/D056735
type	http://www.w3.org/2002/07/owl#Class
tui	T116 T126
cui	C0667830 C0913626
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528 See more See less
TERMUI	T313158 T313161 T313159 T412533 T313160 T313162 T412532 T313163 See more See less

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