Medical Subject Headings

Last uploaded: March 22, 2026

Id	http://purl.bioontology.org/ontology/MESH/D051059 http://purl.bioontology.org/ontology/MESH/D051059
Preferred Name	PTEN Phosphohydrolase
Definitions	A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.
Synonyms	MMAC1 Protein Phosphatase, PTEN Protein Phosphatase, PTEN PTEN Phosphatase PTEN Protein Phosphatase PTEN Protein Phosphatase and Tensin Homologue on Chromosome Ten Protein Phosphatase, PTEN Protein Mutated In Multiple Advanced Cancers 1 Protein Phosphohydrolase, PTEN
Type	http://www.w3.org/2002/07/owl#Class

definition	A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.
altLabel	MMAC1 Protein Phosphatase, PTEN Protein Phosphatase, PTEN PTEN Phosphatase PTEN Protein Phosphatase PTEN Protein Phosphatase and Tensin Homologue on Chromosome Ten Protein Phosphatase, PTEN Protein Mutated In Multiple Advanced Cancers 1 Protein Phosphohydrolase, PTEN See more See less
prefLabel	PTEN Phosphohydrolase
Machine permutation	2006; PTEN PROTEIN was indexed under PROTEIN-TYROSINE-PHOSPHATASES 1997-1998, under TUMOR SUPPRESSOR PROTEINS 1997-2005, & under PHOSPHORIC MONOESTER HYDROLASES 1999-2005
HN	2006(1997)
Mapped from	http://purl.bioontology.org/ontology/MESH/C436505 http://purl.bioontology.org/ontology/MESH/C487757 http://purl.bioontology.org/ontology/MESH/C487101 http://purl.bioontology.org/ontology/MESH/C526890 http://purl.bioontology.org/ontology/MESH/C470418 http://purl.bioontology.org/ontology/MESH/C446603 http://purl.bioontology.org/ontology/MESH/C494929 http://purl.bioontology.org/ontology/MESH/C487216 See more See less
type	http://www.w3.org/2002/07/owl#Class
tui	T116 T126
TERMUI	T629531 T000887855 T633719 T627344 T627346 T627345 T627343 See more See less
TH	NLM (2006) NLM (2017)
MMR	20151123
notation	D051059
Semantic type UMLS property	http://purl.bioontology.org/ontology/STY/T126 http://purl.bioontology.org/ontology/STY/T116
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528 See more See less
DX	20060101
cui	C1530899
DC	1
MN	D12.776.476.590 D08.811.277.352.650.850 D12.776.624.776.695
AQL	AD AE AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
Inverse of RB	EC 3.1.3.67
MDA	20050202
subClassOf	http://purl.bioontology.org/ontology/MESH/D047908 http://purl.bioontology.org/ontology/MESH/D025521 http://purl.bioontology.org/ontology/MESH/D010744

Add comment

Add proposal

Subscribe to notes emails

Delete	Subject	Author	Type	Created
No notes to display