Medical Subject Headings

Last uploaded: March 22, 2026

Id	http://purl.bioontology.org/ontology/MESH/D050717 http://purl.bioontology.org/ontology/MESH/D050717
Preferred Name	Retinoblastoma-Like Protein p130
Definitions	A negative regulator of the CELL CYCLE that undergoes PHOSPHORYLATION by CYCLIN-DEPENDENT KINASES. RBL2 contains a conserved pocket region that binds E2F4 TRANSCRIPTION FACTOR and E2F5 TRANSCRIPTION FACTOR. RBL2 also interacts with viral ONCOPROTEINS such as POLYOMAVIRUS TUMOR ANTIGENS; ADENOVIRUS E1A PROTEINS; and PAPILLOMAVIRUS E7 PROTEINS.
Synonyms	RBL2 Protein Retinoblastoma Like Protein 2 Retinoblastoma Like Protein p130 p130, Retinoblastoma-Like Protein Retinoblastoma-Like Protein 2
Type	http://www.w3.org/2002/07/owl#Class

definition	A negative regulator of the CELL CYCLE that undergoes PHOSPHORYLATION by CYCLIN-DEPENDENT KINASES. RBL2 contains a conserved pocket region that binds E2F4 TRANSCRIPTION FACTOR and E2F5 TRANSCRIPTION FACTOR. RBL2 also interacts with viral ONCOPROTEINS such as POLYOMAVIRUS TUMOR ANTIGENS; ADENOVIRUS E1A PROTEINS; and PAPILLOMAVIRUS E7 PROTEINS.
altLabel	RBL2 Protein Retinoblastoma Like Protein 2 Retinoblastoma Like Protein p130 p130, Retinoblastoma-Like Protein Retinoblastoma-Like Protein 2
prefLabel	Retinoblastoma-Like Protein p130
Machine permutation	2006; RETINOBLASTOMA-LIKE PROTEIN P130 was indexed under PROTEIN 2004-2005, under ADAPTOR PROTEINS 2004, under PHOSPHOPROTEINS 1996-2004, & under PROTEINS 1994-1995
HN	2006(1994)
Mapped from	http://purl.bioontology.org/ontology/MESH/C493839 http://purl.bioontology.org/ontology/MESH/C493838 http://purl.bioontology.org/ontology/MESH/C493837
type	http://www.w3.org/2002/07/owl#Class
tui	T116 T123
TERMUI	T622666 T636786 T622664 T629639
TH	NLM (2006)
MMR	20060101
notation	D050717
Semantic type UMLS property	http://purl.bioontology.org/ontology/STY/T123 http://purl.bioontology.org/ontology/STY/T116
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528 See more See less
DX	20060101
cui	C1529719
DC	1
MN	D12.776.624.776.735 D12.776.744.755 D12.776.660.794
AQL	AD AE AG AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
Inverse of RB	0
MDA	20050203
subClassOf	http://purl.bioontology.org/ontology/MESH/D025521 http://purl.bioontology.org/ontology/MESH/D010750 http://purl.bioontology.org/ontology/MESH/D009687

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