Medical Subject Headings

Last uploaded: January 16, 2025

Id	http://purl.bioontology.org/ontology/MESH/D049993 http://purl.bioontology.org/ontology/MESH/D049993
Preferred Name	Sodium Chloride Symporter Inhibitors
Definitions	Diuretics characterized as analogs of 1,2,4-benzothiadiazine-1,1-dioxide. All have a common mechanism of action and differ primarily in the dose required to produce a given effect. They act directly on the kidney to increase the excretion of sodium chloride and water. Also, diuretics increase excretion of potassium ions. Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA.
Synonyms	Thiazide Sensitive NaCl Cotransporter Inhibitors Sodium Chloride Cotransporter Inhibitor Potassium Depleting Diuretics Potassium Depleting Diuretic Sodium Chloride Symporter Inhibitor Diuretics, Thiazide Benzothiadiazine Diuretic Diuretics, Benzothiadiazine Thiazide Diuretics Diuretic, Potassium Depleting Diuretics, Potassium Depleting Thiazide Diuretic Diuretic, Benzothiadiazine Benzothiadiazine Diuretics Diuretic, Thiazide Thiazide Sensitive NaCl Cotransporter Inhibitor Depleting Diuretic, Potassium Sodium Chloride Cotransporter Inhibitors See more See less
Type	http://www.w3.org/2002/07/owl#Class

definition	Diuretics characterized as analogs of 1,2,4-benzothiadiazine-1,1-dioxide. All have a common mechanism of action and differ primarily in the dose required to produce a given effect. They act directly on the kidney to increase the excretion of sodium chloride and water. Also, diuretics increase excretion of potassium ions. Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA.
altLabel	Thiazide Sensitive NaCl Cotransporter Inhibitors Sodium Chloride Cotransporter Inhibitor Potassium Depleting Diuretics Potassium Depleting Diuretic Sodium Chloride Symporter Inhibitor Diuretics, Thiazide Benzothiadiazine Diuretic Diuretics, Benzothiadiazine Thiazide Diuretics Diuretic, Potassium Depleting Diuretics, Potassium Depleting Thiazide Diuretic Diuretic, Benzothiadiazine Benzothiadiazine Diuretics Diuretic, Thiazide Thiazide Sensitive NaCl Cotransporter Inhibitor Depleting Diuretic, Potassium Sodium Chloride Cotransporter Inhibitors See more See less
prefLabel	Sodium Chloride Symporter Inhibitors
TH	UNK (19XX) NLM (2021) NLM (2006) NLM (1974)
notation	D049993
DX	20060101
Machine permutation	2006; for THIAZIDE DIURETICS use THIAZIDE DIURETICS 1976-2005
MN	D27.505.696.560.500.863 D27.505.519.562.812
MMR	20210630
AQL	AD AE AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
HN	2006
subClassOf	http://purl.bioontology.org/ontology/MESH/D004232 http://purl.bioontology.org/ontology/MESH/D049990
Semantic type UMLS property	http://purl.bioontology.org/ontology/STY/T121
Inverse of isa	http://purl.bioontology.org/ontology/MESH/D002752 http://purl.bioontology.org/ontology/MESH/D011139 http://purl.bioontology.org/ontology/MESH/D003518 http://purl.bioontology.org/ontology/MESH/D008788 http://purl.bioontology.org/ontology/MESH/C050700 http://purl.bioontology.org/ontology/MESH/D006857 http://purl.bioontology.org/ontology/MESH/D006852 http://purl.bioontology.org/ontology/MESH/C436283 http://purl.bioontology.org/ontology/MESH/D001539 http://purl.bioontology.org/ontology/MESH/D008736 http://purl.bioontology.org/ontology/MESH/C044959 http://purl.bioontology.org/ontology/MESH/D002740 http://purl.bioontology.org/ontology/MESH/D014237 http://purl.bioontology.org/ontology/MESH/D007190 See more See less
Inverse of RB	0
DC	1
MDA	20050630
type	http://www.w3.org/2002/07/owl#Class
tui	T121
cui	C0012802 C1563712 C1563711
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528 See more See less
TERMUI	T000997938 T000997935 T012862 T012863 T000997940 T012861 T000997936 T607553 T000997937 T607552 T000997939 T607554 T607551 See more See less

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