Medical Subject Headings

Last uploaded: August 28, 2024

Preferred Name	Histamine H1 Antagonists, Non-Sedating
Synonyms	Second Generation H1 Antagonists Second Generation H1 Antagonist Generation Antihistamine, Second Antihistamines, Second Generation H1 Antihistamines, Non Sedating Non-Sedating H1 Antihistamines Antihistamine, Second Generation Second Generation Antihistamines Histamine H1 Antagonists, Non Sedating Third Generation H1 Antagonist H1 Antihistamines, Non-Sedating Second Generation Antihistamine Third Generation H1 Antagonists
Definitions	A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment. Active enantiomers and selective derivatives of second generation H1 antagonists.
ID	http://purl.bioontology.org/ontology/MESH/D039563
altLabel	Second Generation H1 Antagonists Second Generation H1 Antagonist Generation Antihistamine, Second Antihistamines, Second Generation H1 Antihistamines, Non Sedating Non-Sedating H1 Antihistamines Antihistamine, Second Generation Second Generation Antihistamines Histamine H1 Antagonists, Non Sedating Third Generation H1 Antagonist H1 Antihistamines, Non-Sedating Second Generation Antihistamine Third Generation H1 Antagonists
AQL	AD AE AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
cui	C1136312 C1956397
DC	1
definition	A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment. Active enantiomers and selective derivatives of second generation H1 antagonists.
DX	20030101
FX	D018926
HN	2003
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of isa	http://purl.bioontology.org/ontology/MESH/C020976 http://purl.bioontology.org/ontology/MESH/D016593 http://purl.bioontology.org/ontology/MESH/C043648 http://purl.bioontology.org/ontology/MESH/C047340 http://purl.bioontology.org/ontology/MESH/D000069605 http://purl.bioontology.org/ontology/MESH/C472067 http://purl.bioontology.org/ontology/MESH/D017332 http://purl.bioontology.org/ontology/MESH/D017336 http://purl.bioontology.org/ontology/MESH/C093230 http://purl.bioontology.org/ontology/MESH/C121345 http://purl.bioontology.org/ontology/MESH/C076170 http://purl.bioontology.org/ontology/MESH/D016589
Inverse of RB	0
Inverse of RO	http://purl.bioontology.org/ontology/MESH/D018926
Machine permutation	2003
MDA	20020702
MMR	20200527
MN	D27.505.519.625.375.425.400.500 D27.505.696.577.375.425.400.500
notation	D039563
prefLabel	Histamine H1 Antagonists, Non-Sedating
TERMUI	T686139 T000997692 T494685 T488201 T000997693 T488202 T000997694 T494686
TH	NLM (2008) NLM (2021) NLM (2003)
tui	T109 T121
subClassOf	http://purl.bioontology.org/ontology/MESH/D006634

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/MSHFRE/D039563	MSHFRE	CUI
http://purl.bioontology.org/ontology/MSHFRE/D039563	MSHFRE	CUI
http://purl.bioontology.org/ontology/RCD/x01Do	RCD	CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D27.505.519.625.375.425.400.500	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D039563	RH-MESH	LOOM
http://doe-generated-ontology.com/OntoAD#C1136312	ONTOAD	LOOM
http://purl.obolibrary.org/obo/OMIT_0022926	OMIT	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00024663	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/MESH_D039563	BERO	LOOM
http://purl.jp/bio/4/id/200906038271360650	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D27.505.696.577.375.425.400.500	RH-MESH	LOOM