loading...| Preferred Name | RNA Interference | |
| Synonyms |
Post-Transcriptional Gene Silencing Gene Silencing, Post Transcriptional Co Suppression Gene Silencing, Post-Transcriptional Gene Silencings, Posttranscriptional Cosuppression RNA Silencing Posttranscriptional Gene Silencing Post Transcriptional Gene Silencing RNAi Silencing, Post-Transcriptional Gene Post-Transcriptional Gene Silencings Interference, RNA Gene Silencing, Posttranscriptional Co-Suppression |
|
| Definitions |
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process. Joint gene silencing of extra copies of genes, such as TRANSGENES, along with the original endogenous gene. Cosuppression is induced by the presence of the extra gene copies via mechanisms that are related to RNA INTERFERENCE. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D034622 |
|
| altLabel |
Post-Transcriptional Gene Silencing Gene Silencing, Post Transcriptional Co Suppression Gene Silencing, Post-Transcriptional Gene Silencings, Posttranscriptional Cosuppression RNA Silencing Posttranscriptional Gene Silencing Post Transcriptional Gene Silencing RNAi Silencing, Post-Transcriptional Gene Post-Transcriptional Gene Silencings Interference, RNA Gene Silencing, Posttranscriptional Co-Suppression |
|
| AQL |
DE IM PH RE |
|
| cui |
C1956351 C1136031 |
|
| DC |
1 |
|
| definition |
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process. Joint gene silencing of extra copies of genes, such as TRANSGENES, along with the original endogenous gene. Cosuppression is induced by the presence of the extra gene copies via mechanisms that are related to RNA INTERFERENCE. |
|
| DX |
20030101 |
|
| FX |
D000067492 D034741 D034743 |
|
| HN |
2003 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000502 |
|
| Inverse of RO |
http://purl.bioontology.org/ontology/MESH/D034741 http://purl.bioontology.org/ontology/MESH/D034743 |
|
| Machine permutation |
2003 |
|
| MDA |
20020703 |
|
| MMR |
20160617 |
|
| MN |
G05.308.203.374.790 |
|
| notation |
D034622 |
|
| prefLabel |
RNA Interference |
|
| TERMUI |
T471542 T000870922 T471540 T471584 T695254 T471541 T471539 T695255 |
|
| TH |
NLM (2016) NLM (2008) NLM (2003) |
|
| tui |
T045 |
|
| subClassOf |