| Preferred Name |
Mitogen-Activated Protein Kinase Kinases
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| Synonyms |
MAPK-ERK Kinase
MAPKKs
Kinase, MAPK-ERK
MAPKK
Mitogen Activated Protein Kinase Kinases
MAP ERK Kinase
MEK
MAPK-ERK Kinases
MAPK Kinases
Kinases, MAPK-ERK
Kinases, MAP Kinase
MAPK ERK Kinase
Kinase Kinases, MAP
Kinase Kinase, Map
Mitogen-Activated Protein Kinase Kinase
MAP Kinase Kinases
Kinases, MAPK
Kinase, MAPK
Map Kinase Kinase
Mitogen Activated Protein Kinase Kinase
MAP-ERK Kinase
MAPK Kinase
Kinase, MAP-ERK
MEKs
MAPK ERK Kinases
Kinase, Map Kinase
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| Definitions |
A dual-specific protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.
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| ID |
http://purl.bioontology.org/ontology/MESH/D020929
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| altLabel |
MAPK-ERK Kinase MAPKKs Kinase, MAPK-ERK MAPKK Mitogen Activated Protein Kinase Kinases MAP ERK Kinase MEK MAPK-ERK Kinases MAPK Kinases Kinases, MAPK-ERK Kinases, MAP Kinase MAPK ERK Kinase Kinase Kinases, MAP Kinase Kinase, Map Mitogen-Activated Protein Kinase Kinase MAP Kinase Kinases Kinases, MAPK Kinase, MAPK Map Kinase Kinase Mitogen Activated Protein Kinase Kinase MAP-ERK Kinase MAPK Kinase Kinase, MAP-ERK MEKs MAPK ERK Kinases Kinase, Map Kinase
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| AQL |
AD AE AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
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| cui |
C0752313 C0169101
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| DC |
1
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| definition |
A dual-specific protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.
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| DX |
20000101
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| FX |
D020935
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| HN |
2000; for MAP-ERK KINASE use MEK1 PROTEIN (NM) 1992-1999
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| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
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| Inverse of RB |
EC 2.7.12.2
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| Inverse of RO |
http://purl.bioontology.org/ontology/MESH/D020935
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| Machine permutation |
2000; MAP KINASE KINASE and MAPKK (now MITOGEN-ACTIVATED KINASE KINASES) were indexed under PROTEIN KINASES 1992-1999; MAP-ERK KINASE (now MITOGEN-ACTIVATED KINASE KINASES) was indexed under PROTEIN-TYROSINE KINASE 1992-1999
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| Mapped from |
http://purl.bioontology.org/ontology/MESH/C409022 http://purl.bioontology.org/ontology/MESH/C500415 http://purl.bioontology.org/ontology/MESH/C519872 http://purl.bioontology.org/ontology/MESH/C519871 http://purl.bioontology.org/ontology/MESH/C000616811 http://purl.bioontology.org/ontology/MESH/C488959 http://purl.bioontology.org/ontology/MESH/C107487 http://purl.bioontology.org/ontology/MESH/C089356 http://purl.bioontology.org/ontology/MESH/C571388 http://purl.bioontology.org/ontology/MESH/C089988 http://purl.bioontology.org/ontology/MESH/C117694 http://purl.bioontology.org/ontology/MESH/C503375 http://purl.bioontology.org/ontology/MESH/C000609667 http://purl.bioontology.org/ontology/MESH/C109170 http://purl.bioontology.org/ontology/MESH/C458516 http://purl.bioontology.org/ontology/MESH/C573076 http://purl.bioontology.org/ontology/MESH/C119846 http://purl.bioontology.org/ontology/MESH/C119844 http://purl.bioontology.org/ontology/MESH/C000631068 http://purl.bioontology.org/ontology/MESH/C072068 http://purl.bioontology.org/ontology/MESH/C404401 http://purl.bioontology.org/ontology/MESH/C527379 http://purl.bioontology.org/ontology/MESH/C511060 http://purl.bioontology.org/ontology/MESH/C000593261 http://purl.bioontology.org/ontology/MESH/C561307 http://purl.bioontology.org/ontology/MESH/C419563 http://purl.bioontology.org/ontology/MESH/C072075 http://purl.bioontology.org/ontology/MESH/C414539
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| MDA |
19991103
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| MMR |
20210521
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| MN |
D12.776.476.563.565 D12.776.476.568.200 D08.811.913.696.620.682.725.200 D08.811.913.696.620.682.700.565
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| notation |
D020929
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| prefLabel |
Mitogen-Activated Protein Kinase Kinases
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| RR |
EC 2.7.12.2
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| TERMUI |
T232366 T001010881 T232365 T000997313 T361674 T361672 T358038 T361673 T000997316 T336704 T361671 T000997315 T361670
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| TH |
NLM (2000) NLM (2021)
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| tui |
T116 T126
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| subClassOf |
http://purl.bioontology.org/ontology/MESH/D011505 http://purl.bioontology.org/ontology/MESH/D017346
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