Medical Subject Headings

Last uploaded: August 28, 2024

Preferred Name	Caspases
Synonyms	Caspase
Definitions	A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
ID	http://purl.bioontology.org/ontology/MESH/D020169
altLabel	Caspase
AN	CASPASES, EFFECTOR and CASPASES, INITIATOR and specifics are available
AQL	AD AE AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
cui	C0010656
DC	1
definition	A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
DX	19990101
EC	antagonists & inhibitors:Caspase Inhibitors
FX	D017209
HN	99
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	EC 3.4.22.-
Inverse of RO	http://purl.bioontology.org/ontology/MESH/D017209
Machine permutation	99
Mapped from	http://purl.bioontology.org/ontology/MESH/C400190 http://purl.bioontology.org/ontology/MESH/C554639 http://purl.bioontology.org/ontology/MESH/C506446 http://purl.bioontology.org/ontology/MESH/C506449 http://purl.bioontology.org/ontology/MESH/C431941 http://purl.bioontology.org/ontology/MESH/C431887 http://purl.bioontology.org/ontology/MESH/C099217 http://purl.bioontology.org/ontology/MESH/C089223 http://purl.bioontology.org/ontology/MESH/C438246 http://purl.bioontology.org/ontology/MESH/C491071 http://purl.bioontology.org/ontology/MESH/C513669 http://purl.bioontology.org/ontology/MESH/C582578 http://purl.bioontology.org/ontology/MESH/C554452 http://purl.bioontology.org/ontology/MESH/C554451 http://purl.bioontology.org/ontology/MESH/C000629852 http://purl.bioontology.org/ontology/MESH/C516211 http://purl.bioontology.org/ontology/MESH/C109171 http://purl.bioontology.org/ontology/MESH/C112920 http://purl.bioontology.org/ontology/MESH/C118731 http://purl.bioontology.org/ontology/MESH/C456272 http://purl.bioontology.org/ontology/MESH/C000624929 http://purl.bioontology.org/ontology/MESH/C103568 http://purl.bioontology.org/ontology/MESH/C583895 http://purl.bioontology.org/ontology/MESH/C472302 http://purl.bioontology.org/ontology/MESH/C116781 http://purl.bioontology.org/ontology/MESH/C116783
MDA	19980610
MMR	20210521
MN	D08.811.277.656.262.500.126 D12.776.476.075.405 D08.811.277.656.300.200.126
notation	D020169
prefLabel	Caspases
TERMUI	T059964 T000996200
TH	NLM (1999) NLM (2021)
tui	T116 T126
subClassOf	http://purl.bioontology.org/ontology/MESH/D051017 http://purl.bioontology.org/ontology/MESH/D003546

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/CSP/4007-0033	CRISP	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000170497	NDFRT	CUI
http://purl.bioontology.org/ontology/MSHFRE/D020169	MSHFRE	CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.811.277.656.300.200.126	RH-MESH	LOOM
http://purl.obolibrary.org/obo/OMIT_0020090	OMIT	LOOM
http://purl.jp/bio/4/id/200906006441338966	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.476.075.405	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.811.277.656.262.500.126	RH-MESH	LOOM
http://id.nlm.nih.gov/mesh/D020169	MDM	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D020169	RH-MESH	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00019611	PMAPP-PMO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.360.075.405	RH-MESH	LOOM
http://purl.obolibrary.org/obo/MESH_D020169	BERO	LOOM