Medical Subject Headings

Last uploaded: January 31, 2024

Details
Visualization
Notes ( 0 )
Class Mappings ( )

Preferred Name	eIF-2 Kinase
Synonyms	Kinase, Self-Phosphorylating Protein p68 Kinase Self-Phosphorylating Protein Kinase Kinase, p68 Kinase, DAI Protein Translational Repressor, Heme-Controlled Heme-Regulated eIF-2alpha Kinase Heme Controlled Inhibitor Kinase, p65 DAI Protein Kinase eIF 2alpha Kinase DSRNA-Dep Protein Kinase TIK Kinase RNA-Dependent Protein Kinase Double Stranded RNA Dependent eIF 2 alpha Protein Kinase Kinase PKR, Protein Kinase, P68 Protein Heme Controlled Repressor PKR, Protein Kinase RNA Dependent Protein Kinase Hemin Controlled Translational Repressor DSRNA Dep Protein Kinase Kinase, RNA-Dependent Protein Kinase, eIF-2 dsRNA-Activated Inhibitor dsRNA Activated Inhibitor Inhibitor, dsRNA-Activated Kinase, TIK Heme-Controlled Translational Repressor P68 Protein Kinase Protein Kinase, DAI Protein Kinase, DSRNA-Dep Translational Repressor, Hemin-Controlled Inhibitor, Heme-Controlled eRF, eIF-2 Recycling Factor Protein Kinase, RNA Activated Heme-Controlled Inhibitor Kinase, Heme-Regulated eIF-2alpha Repressor, Hemin Controlled Repressor, Heme Controlled Kinase, DSRNA-Dep Protein p65 Kinase Protein Kinase PKR eIF-2alpha Kinase Self Phosphorylating Protein Kinase Repressor, Hemin-Controlled Translational eRF, eIF 2 Recycling Factor Controlled Repressor, Heme Hemin Controlled Repressor Heme Controlled Translational Repressor Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase Kinase, eIF-2alpha Controlled Repressor, Hemin Heme Regulated eIF 2alpha Kinase Protein Kinase, P68 Eukaryotic Initiation Factor 2alpha Kinase eIF 2 Kinase Hemin-Controlled Translational Repressor Double Stranded RNA-Dependent Kinase (dsl) eIF-2alpha Kinase, Heme-Regulated Protein Kinase, Self-Phosphorylating Protein Kinase, RNA-Dependent Repressor, Heme-Controlled Translational
Definitions	A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.
ID	http://purl.bioontology.org/ontology/MESH/D019892
altLabel	Kinase, Self-Phosphorylating Protein p68 Kinase Self-Phosphorylating Protein Kinase Kinase, p68 Kinase, DAI Protein Translational Repressor, Heme-Controlled Heme-Regulated eIF-2alpha Kinase Heme Controlled Inhibitor Kinase, p65 DAI Protein Kinase eIF 2alpha Kinase DSRNA-Dep Protein Kinase TIK Kinase RNA-Dependent Protein Kinase Double Stranded RNA Dependent eIF 2 alpha Protein Kinase Kinase PKR, Protein Kinase, P68 Protein Heme Controlled Repressor PKR, Protein Kinase RNA Dependent Protein Kinase Hemin Controlled Translational Repressor DSRNA Dep Protein Kinase Kinase, RNA-Dependent Protein Kinase, eIF-2 dsRNA-Activated Inhibitor dsRNA Activated Inhibitor Inhibitor, dsRNA-Activated Kinase, TIK Heme-Controlled Translational Repressor P68 Protein Kinase Protein Kinase, DAI Protein Kinase, DSRNA-Dep Translational Repressor, Hemin-Controlled Inhibitor, Heme-Controlled eRF, eIF-2 Recycling Factor Protein Kinase, RNA Activated Heme-Controlled Inhibitor Kinase, Heme-Regulated eIF-2alpha Repressor, Hemin Controlled Repressor, Heme Controlled Kinase, DSRNA-Dep Protein p65 Kinase Protein Kinase PKR eIF-2alpha Kinase Self Phosphorylating Protein Kinase Repressor, Hemin-Controlled Translational eRF, eIF 2 Recycling Factor Controlled Repressor, Heme Hemin Controlled Repressor Heme Controlled Translational Repressor Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase Kinase, eIF-2alpha Controlled Repressor, Hemin Heme Regulated eIF 2alpha Kinase Protein Kinase, P68 Eukaryotic Initiation Factor 2alpha Kinase eIF 2 Kinase Hemin-Controlled Translational Repressor Double Stranded RNA-Dependent Kinase (dsl) eIF-2alpha Kinase, Heme-Regulated Protein Kinase, Self-Phosphorylating Protein Kinase, RNA-Dependent Repressor, Heme-Controlled Translational
AQL	AD AE AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
cui	C0058980
DC	1
definition	A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.
DX	19980101
HN	98; use EIF-2 KINASE (NM) 1980-97
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	EC 2.7.11.1
Machine permutation	98; EIF-2 KINASE was indexed under PROTEIN-SERINE-THREONINE KINASES 1993-97 & PROTEIN KINASES 1980-93
Mapped from	http://purl.bioontology.org/ontology/MESH/C000605978 http://purl.bioontology.org/ontology/MESH/C000602769 http://purl.bioontology.org/ontology/MESH/C460640 http://purl.bioontology.org/ontology/MESH/C117035 http://purl.bioontology.org/ontology/MESH/C466820 http://purl.bioontology.org/ontology/MESH/C583541 http://purl.bioontology.org/ontology/MESH/C466819
MDA	19970702
MMR	20210521
MN	D12.776.476.563.300 D08.811.913.696.620.682.700.300
notation	D019892
prefLabel	eIF-2 Kinase
TERMUI	T059210 T059222 T059223 T059217 T059224 T059219 T059231 T059229 T059211 T059225 T059228 T059212 T059227 T059232 T059215 T059218 T059230 T059226 T059213 T059221 T059216 T059220 T059214
TH	NLM (1998)
tui	T116 T126
subClassOf	http://purl.bioontology.org/ontology/MESH/D017346

Add comment

Add proposal

Subscribe to notes emails

Delete	Subject	Author	Type	Created
No notes to display

Create mapping

Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/MSHFRE/D019892	MSHFRE	CUI
http://purl.bioontology.org/ontology/CSP/2312-2490	CRISP	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000170522	NDFRT	CUI
http://purl.obolibrary.org/obo/OMIT_0019861	OMIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.476.275	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.360.275	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D019892	RH-MESH	LOOM
http://id.nlm.nih.gov/mesh/D019892	MDM	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00020606	PMAPP-PMO	LOOM
http://purl.jp/bio/4/id/200906043375118960	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.811.913.696.620.682.700.300	RH-MESH	LOOM
http://purl.obolibrary.org/obo/MESH_D019892	BERO	LOOM