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Medical Subject Headings
Last uploaded:
March 22, 2026
| Id | http://purl.bioontology.org/ontology/MESH/D019716
http://purl.bioontology.org/ontology/MESH/D019716
|
|---|---|
| Preferred Name | Tissue Inhibitor of Metalloproteinase-2 |
| Definitions |
A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.
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| Synonyms |
Metalloproteinase-2 Tissue Inhibitor
TIMP-2
Tissue Inhibitor of Metalloproteinase 2
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo. |
|---|---|
| altLabel |
Metalloproteinase-2 Tissue Inhibitor
TIMP-2
Tissue Inhibitor of Metalloproteinase 2
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| prefLabel | Tissue Inhibitor of Metalloproteinase-2
|
| Machine permutation | 1998; TISSUE INHIBITOR OF METALLOPROTEINASE 2 was indexed under PROTEINS 1990-97 & NEOPLASM PROTEINS 1989-1993
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| HN | 1998; see TISSUE INHIBITOR OF METALLOPROTEINASE-2 (NM) 1989-1997
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| Mapped from | |
| type | |
| isa | |
| PA | D061965
|
| tui |
T116
T123
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| TERMUI |
T058647
T058646
|
| TH | NLM (1998)
|
| MMR | 20220712
|
| notation | D019716
|
| Semantic type UMLS property | |
| Inverse of AQ |
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| DX | 19980101
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| cui | C0145946
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| DC | 1
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| MN | D12.776.815.875.500
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| AQL | AD AE AG AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
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| Inverse of RB | 127497-59-0
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| MDA | 19990101
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |