Medical Subject Headings

Last uploaded: March 22, 2026

Id	http://purl.bioontology.org/ontology/MESH/D019332 http://purl.bioontology.org/ontology/MESH/D019332
Preferred Name	Endothelin-1
Definitions	A 38 amino acid form of endothelin-1 that results from alternative processing of proendothelin-1. A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
Synonyms	Preproendothelin Big Endothelin Endothelin-1, Big Endothelin Type 1 Big Endothelin-1 Proendothelin 1 Precursor Proendothelin-1 Precursor Proendothelin (1-38) Big Endothelin 1 Preproendothelin-1 Precursor, Proendothelin-1 Endothelin, Big Endothelin 1 Preproendothelin 1 See more See less
Type	http://www.w3.org/2002/07/owl#Class

definition	A 38 amino acid form of endothelin-1 that results from alternative processing of proendothelin-1. A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
altLabel	Preproendothelin Big Endothelin Endothelin-1, Big Endothelin Type 1 Big Endothelin-1 Proendothelin 1 Precursor Proendothelin-1 Precursor Proendothelin (1-38) Big Endothelin 1 Preproendothelin-1 Precursor, Proendothelin-1 Endothelin, Big Endothelin 1 Preproendothelin 1 See more See less
prefLabel	Endothelin-1
Machine permutation	2004; see ENDOTHELINS 1991-1996; BIG ENDOTHELIN was indexed under ENDTHELINS & PROTEIN PRECUSORS 1991-2003; under PEPTIDES 1990; PREPROENDOTHELIN was indexed under ENDOTHELINS & PROTEIN PRECUSORS 1989-2003
HN	2004(1997); use ENDOTHELINS 1991-96; for BIG ENDOTHELIN use ENDOTHELIN-1 (NM) 1990-2003; for PREPROENDOLTHELIN use ENDOTHELINS-1 (NM) 1989-2003
Mapped from	http://purl.bioontology.org/ontology/MESH/C112014 http://purl.bioontology.org/ontology/MESH/C119962 http://purl.bioontology.org/ontology/MESH/C121499 http://purl.bioontology.org/ontology/MESH/C106977 http://purl.bioontology.org/ontology/MESH/C106975 http://purl.bioontology.org/ontology/MESH/C116745 http://purl.bioontology.org/ontology/MESH/C082875 http://purl.bioontology.org/ontology/MESH/C095657 http://purl.bioontology.org/ontology/MESH/C089337 http://purl.bioontology.org/ontology/MESH/C089336 http://purl.bioontology.org/ontology/MESH/C093152 http://purl.bioontology.org/ontology/MESH/C419584 http://purl.bioontology.org/ontology/MESH/C073614 http://purl.bioontology.org/ontology/MESH/C116592 http://purl.bioontology.org/ontology/MESH/C086215 http://purl.bioontology.org/ontology/MESH/C414282 http://purl.bioontology.org/ontology/MESH/C575335 http://purl.bioontology.org/ontology/MESH/C114932 http://purl.bioontology.org/ontology/MESH/C557077 http://purl.bioontology.org/ontology/MESH/C093240 See more See less
type	http://www.w3.org/2002/07/owl#Class
tui	T116 T123
TERMUI	T529418 T197681 T204538 T197680 T204540 T057624 T204541 T204539 T197682 See more See less
TH	NLM (1997) NLM (2004)
MMR	20150626
notation	D019332
Semantic type UMLS property	http://purl.bioontology.org/ontology/STY/T123 http://purl.bioontology.org/ontology/STY/T116
RR	122462-75-3 114540-95-3
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528 See more See less
DX	19970101
cui	C0053571 C0079281 C0071923
DC	1
MN	D12.776.467.400.225 D12.644.276.400.225 D23.529.400.225
AN	/drug eff permitted
AQL	AA AD AE AG AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UR
Inverse of RB	122462-75-3 114540-95-3 0
MDA	19990101
subClassOf	http://purl.bioontology.org/ontology/MESH/D016232

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