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Medical Subject Headings
Last uploaded:
March 22, 2026
| Id | http://purl.bioontology.org/ontology/MESH/D019328
http://purl.bioontology.org/ontology/MESH/D019328
|
|---|---|
| Preferred Name | Buthionine Sulfoximine |
| Definitions |
A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
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| Synonyms |
Sulfoximine, Buthionine
Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7) |
|---|---|
| altLabel |
Sulfoximine, Buthionine
Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-
|
| prefLabel | Buthionine Sulfoximine
|
| Machine permutation | 97; BUTHIONINE SULFOXIMINE was indexed under METHIONINE SULFOXIMINE 1979-96
|
| HN | 97: was BUTHIONINE SULFOXIMINE (NM) 1979-96
|
| type | |
| isa | |
| PA |
D011838
D011837
D004791
D000964
D000963
|
| tui |
T116
T131
T121
|
| TERMUI | T057614
|
| TH | NLM (1997)
|
| MMR | 20050630
|
| notation | D019328
|
| Semantic type UMLS property | |
| Inverse of AQ |
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|
| DX | 19970101
|
| cui | C0054252
|
| DC | 1
|
| MN |
D02.886.030.676.620.125
D12.125.166.676.620.125
|
| AQL | AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
|
| Inverse of RB | 5072-26-4
|
| OL | use BUTHIONINE SULFOXIMINE (NM) to search BUTHIONINE SULFOXIMINE 1980-96
|
| MDA | 19990101
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |