Antineoplastic Agents, Alkylating

Antineoplastic Drugs, Alkylating

A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)

http://purl.bioontology.org/ontology/MESH/D018906

Antineoplastic Drugs, Alkylating

Alkylating Antineoplastic Agents

Alkylating Antineoplastics

Antineoplastics, Alkylating

Alkylating Drugs, Antineoplastic

Antineoplastic Alkylating Drugs

Alkylating Agents, Antineoplastic

Drugs, Antineoplastic Alkylating

Alkylating Antineoplastic Drugs

Antineoplastic Alkylating Agents

AD AE AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR

C0282532

1

A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)

19960101

96

http://purl.bioontology.org/ontology/MESH/Q000097

http://purl.bioontology.org/ontology/MESH/Q000627

http://purl.bioontology.org/ontology/MESH/Q000493

http://purl.bioontology.org/ontology/MESH/Q000494

http://purl.bioontology.org/ontology/MESH/Q000276

http://purl.bioontology.org/ontology/MESH/Q000138

http://purl.bioontology.org/ontology/MESH/Q000134

http://purl.bioontology.org/ontology/MESH/Q000266

http://purl.bioontology.org/ontology/MESH/Q000378

http://purl.bioontology.org/ontology/MESH/Q000008

http://purl.bioontology.org/ontology/MESH/Q000009

http://purl.bioontology.org/ontology/MESH/Q000032

http://purl.bioontology.org/ontology/MESH/Q000191

http://purl.bioontology.org/ontology/MESH/Q000302

http://purl.bioontology.org/ontology/MESH/Q000145

http://purl.bioontology.org/ontology/MESH/Q000592

http://purl.bioontology.org/ontology/MESH/Q000737

http://purl.bioontology.org/ontology/MESH/Q000506

http://purl.bioontology.org/ontology/MESH/Q000633

http://purl.bioontology.org/ontology/MESH/Q000600

http://purl.bioontology.org/ontology/MESH/Q000652

http://purl.bioontology.org/ontology/MESH/Q000528

http://purl.bioontology.org/ontology/MESH/D009588

http://purl.bioontology.org/ontology/MESH/C001899

http://purl.bioontology.org/ontology/MESH/D013852

http://purl.bioontology.org/ontology/MESH/D014499

http://purl.bioontology.org/ontology/MESH/D007069

http://purl.bioontology.org/ontology/MESH/C474180

http://purl.bioontology.org/ontology/MESH/C091910

http://purl.bioontology.org/ontology/MESH/D000069461

http://purl.bioontology.org/ontology/MESH/C087955

http://purl.bioontology.org/ontology/MESH/C087957

http://purl.bioontology.org/ontology/MESH/D003606

http://purl.bioontology.org/ontology/MESH/D014265

http://purl.bioontology.org/ontology/MESH/C086920

http://purl.bioontology.org/ontology/MESH/D008927

http://purl.bioontology.org/ontology/MESH/C018782

http://purl.bioontology.org/ontology/MESH/D005020

http://purl.bioontology.org/ontology/MESH/C102714

http://purl.bioontology.org/ontology/MESH/D000077204

http://purl.bioontology.org/ontology/MESH/D005009

http://purl.bioontology.org/ontology/MESH/C007526

http://purl.bioontology.org/ontology/MESH/D002330

http://purl.bioontology.org/ontology/MESH/C007779

http://purl.bioontology.org/ontology/MESH/D004961

http://purl.bioontology.org/ontology/MESH/D003961

http://purl.bioontology.org/ontology/MESH/D006585

http://purl.bioontology.org/ontology/MESH/C060090

http://purl.bioontology.org/ontology/MESH/C072257

http://purl.bioontology.org/ontology/MESH/D000816

http://purl.bioontology.org/ontology/MESH/D008130

http://purl.bioontology.org/ontology/MESH/D013721

http://purl.bioontology.org/ontology/MESH/C060649

http://purl.bioontology.org/ontology/MESH/C060648

http://purl.bioontology.org/ontology/MESH/C058289

http://purl.bioontology.org/ontology/MESH/D010440

http://purl.bioontology.org/ontology/MESH/D002225

http://purl.bioontology.org/ontology/MESH/C579022

http://purl.bioontology.org/ontology/MESH/C057900

http://purl.bioontology.org/ontology/MESH/C057901

http://purl.bioontology.org/ontology/MESH/C000629406

http://purl.bioontology.org/ontology/MESH/D008558

http://purl.bioontology.org/ontology/MESH/C027061

http://purl.bioontology.org/ontology/MESH/D012673

http://purl.bioontology.org/ontology/MESH/D008741

http://purl.bioontology.org/ontology/MESH/C003726

http://purl.bioontology.org/ontology/MESH/C018627

http://purl.bioontology.org/ontology/MESH/D003520

http://purl.bioontology.org/ontology/MESH/D014228

http://purl.bioontology.org/ontology/MESH/C092034

http://purl.bioontology.org/ontology/MESH/D010752

http://purl.bioontology.org/ontology/MESH/D000080890

http://purl.bioontology.org/ontology/MESH/D010885

http://purl.bioontology.org/ontology/MESH/D011238

http://purl.bioontology.org/ontology/MESH/C018404

http://purl.bioontology.org/ontology/MESH/C076570

http://purl.bioontology.org/ontology/MESH/D008936

http://purl.bioontology.org/ontology/MESH/C066098

http://purl.bioontology.org/ontology/MESH/C406024

http://purl.bioontology.org/ontology/MESH/D008357

http://purl.bioontology.org/ontology/MESH/D002066

http://purl.bioontology.org/ontology/MESH/D002699

http://purl.bioontology.org/ontology/MESH/D008466

http://purl.bioontology.org/ontology/MESH/C066900

http://purl.bioontology.org/ontology/MESH/D000077606

0

96

19950526

20140625

D27.505.954.248.150

D27.505.519.124.035

D27.888.569.035.035

D018906

Antineoplastic Agents, Alkylating

T056350

T056346

T056345

T056348

T056347

T056349

T056344

T056352

T056351

NLM (1996)

T121

http://purl.bioontology.org/ontology/MESH/D000970

http://purl.bioontology.org/ontology/MESH/D000477