Link to this page
Medical Subject Headings
Last uploaded:
March 22, 2026
| Id | http://purl.bioontology.org/ontology/MESH/D018435
http://purl.bioontology.org/ontology/MESH/D018435
|
|---|---|
| Preferred Name | ATP Binding Cassette Transporter, Subfamily B |
| Definitions |
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to ATP-BINDING CASSETTE, SUB-FAMILY C PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
|
| Synonyms |
ATP Binding Cassette Transporter, Sub Family B
ATP Binding Cassette Transporter, Sub-Family B
P Glycoproteins
P-Glycoproteins
ATP-Binding Cassette, Sub-Family B Proteins
Multidrug Resistance Proteins
ATP Binding Cassette, Sub Family B Proteins
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to ATP-BINDING CASSETTE, SUB-FAMILY C PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology. |
|---|---|
| altLabel |
ATP Binding Cassette Transporter, Sub Family B
ATP Binding Cassette Transporter, Sub-Family B
P Glycoproteins
P-Glycoproteins
ATP-Binding Cassette, Sub-Family B Proteins
Multidrug Resistance Proteins
ATP Binding Cassette, Sub Family B Proteins
See more
See less
|
| prefLabel | ATP Binding Cassette Transporter, Subfamily B
|
| Machine permutation | 2019; see ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY B 2018; see P-GLYCOPROTEIN 1995-1998; P-GLYCOPROTEIN was indexed under CARRIER PROTEINS & MEMBRANE GLYCOPROTEINS 1980-1994, GLYCOPROTEINS 1980-1987, and MEMBRANE PROTEINS 1980-1982
|
| HN | 2019 (1999); use P-GLYCOPROTEIN 1995-1998
|
| Mapped from |
See more
See less
|
| type | |
| tui |
T116
T123
|
| TERMUI |
T439155
T054924
T000938094
T000915448
T442814
|
| TH |
NLM (2002)
NLM (1995)
NLM (2019)
NLM (2018)
|
| MMR | 20260101
|
| notation | D018435
|
| Inverse of RO | |
| Semantic type UMLS property | |
| Inverse of AQ |
See more
See less
|
| FX |
D019450
D018432
D020112
D027425
|
| DX | 19950101
|
| cui | C0069906
|
| DC | 1
|
| MN |
D12.776.395.550.020.400
D12.776.157.530.100.075
D12.776.157.530.450.074.500.500.250
D12.776.543.550.192.400
D12.776.543.585.100.200
D12.776.543.585.450.074.500.500.250
D09.400.430.890.020.400
See more
See less
|
| AN | note entry term: ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 is also available
|
| AQL | AD AE AG AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
|
| Inverse of RB | 0
|
| MDA | 20171221
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |