loading...| Preferred Name |
Mice, Knockout |
|
| Synonyms |
Mice, Knock-out Mice, Knock out |
|
| Definitions |
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D018345 |
|
| altLabel |
Mice, Knock-out Mouse, Knockout Knock-out Mice Knockout Mice Knockout Mouse Mice, Knock out |
|
| AN |
NIM no qualif when exper animal; do not forget also to check MICE |
|
| AQL |
AB AH BL CF CL EM GD GE IM IN ME MI PH PS PX SU UR VI |
|
| cui |
C0206745 |
|
| DC |
1 |
|
| definition |
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes. |
|
| DX |
19940101 |
|
| FX |
D055786 |
|
| HN |
94 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000469 http://purl.bioontology.org/ontology/MESH/Q000002 http://purl.bioontology.org/ontology/MESH/Q000033 http://purl.bioontology.org/ontology/MESH/Q000821 http://purl.bioontology.org/ontology/MESH/Q000254 http://purl.bioontology.org/ontology/MESH/Q000196 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000293 http://purl.bioontology.org/ontology/MESH/Q000382 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000601 |
|
| Inverse of RO | ||
| Machine permutation |
94 |
|
| MDA |
19930603 |
|
| MMR |
20200902 |
|
| MN |
B01.050.150.900.649.313.992.635.505.500.800.500 B01.050.150.900.649.313.992.635.505.500.550.455 B01.050.050.136.500.500 |
|
| notation |
D018345 |
|
| prefLabel |
Mice, Knockout |
|
| TERMUI |
T054741 T519974 T054742 T054740 |
|
| TH |
NLM (2004) NLM (1994) |
|
| tui |
T015 |
|
| subClassOf |