Medical Subject Headings

Last uploaded: August 28, 2024

Preferred Name	Tacrolimus
Synonyms	Tacrolimus Anhydrous Anhydrous, Tacrolimus FK506 FR-900506 Anhydrous Tacrolimus 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S-(3R(E(1S,3S,4S)),4S,5R,8S,9E,12R,14R,15S,16R,18S,19S,26aR))- Tacrolimus, Anhydrous FK-506 FR 900506 Prograf FK 506 Prograft FR900506
Definitions	A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
ID	http://purl.bioontology.org/ontology/MESH/D016559
altLabel	Tacrolimus Anhydrous Anhydrous, Tacrolimus FK506 FR-900506 Anhydrous Tacrolimus 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S-(3R(E(1S,3S,4S)),4S,5R,8S,9E,12R,14R,15S,16R,18S,19S,26aR))- Tacrolimus, Anhydrous FK-506 FR 900506 Prograf FK 506 Prograft FR900506
AQL	AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
cui	C0678125 C0771204 C0729219 C0729218 C0085149
DC	1
definition	A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
DX	19920101
HN	96; was FK-506 1992-95, was FK 506 (NM) 1987-91
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	WM0HAQ4WNM Y5L2157C4J 0
isa	http://purl.bioontology.org/ontology/MESH/D065095 http://purl.bioontology.org/ontology/MESH/D007166
LT	TRD
Machine permutation	96; was FK-506 1992-95; FK-506 was indexed under ANTIBIOTICS, MACROLIDE 1989-91 & PYRIDINES 1987-89
Mapped from	http://purl.bioontology.org/ontology/MESH/C121816 http://purl.bioontology.org/ontology/MESH/C402181 http://purl.bioontology.org/ontology/MESH/C485833 http://purl.bioontology.org/ontology/MESH/C084260 http://purl.bioontology.org/ontology/MESH/C084050 http://purl.bioontology.org/ontology/MESH/C503135 http://purl.bioontology.org/ontology/MESH/C119717 http://purl.bioontology.org/ontology/MESH/C098646 http://purl.bioontology.org/ontology/MESH/C463061 http://purl.bioontology.org/ontology/MESH/C076383 http://purl.bioontology.org/ontology/MESH/C116704 http://purl.bioontology.org/ontology/MESH/C455240 http://purl.bioontology.org/ontology/MESH/C107028 http://purl.bioontology.org/ontology/MESH/C107029 http://purl.bioontology.org/ontology/MESH/C087154 http://purl.bioontology.org/ontology/MESH/C087153 http://purl.bioontology.org/ontology/MESH/C112843 http://purl.bioontology.org/ontology/MESH/C079136 http://purl.bioontology.org/ontology/MESH/C102348 http://purl.bioontology.org/ontology/MESH/C084049 http://purl.bioontology.org/ontology/MESH/C084048 http://purl.bioontology.org/ontology/MESH/C110188 http://purl.bioontology.org/ontology/MESH/C400076 http://purl.bioontology.org/ontology/MESH/C523600 http://purl.bioontology.org/ontology/MESH/C097667 http://purl.bioontology.org/ontology/MESH/C074833 http://purl.bioontology.org/ontology/MESH/C102915 http://purl.bioontology.org/ontology/MESH/C112418 http://purl.bioontology.org/ontology/MESH/C098104 http://purl.bioontology.org/ontology/MESH/C098493 http://purl.bioontology.org/ontology/MESH/C099298 http://purl.bioontology.org/ontology/MESH/C099297 http://purl.bioontology.org/ontology/MESH/C099294 http://purl.bioontology.org/ontology/MESH/C099296 http://purl.bioontology.org/ontology/MESH/C099295 http://purl.bioontology.org/ontology/MESH/C058028 http://purl.bioontology.org/ontology/MESH/C492680 http://purl.bioontology.org/ontology/MESH/C505380 http://purl.bioontology.org/ontology/MESH/C486238 http://purl.bioontology.org/ontology/MESH/C117268
MDA	19910424
MMR	20160701
MN	D02.540.505.810
notation	D016559
OL	use TACROLIMUS (NM) to search FK-506 1987-91
PA	D065095 D007166
prefLabel	Tacrolimus
RR	109581-93-3 (Tacrolimus) Y5L2157C4J
TERMUI	T049537 T049539 T619253 T822955 T049536 T049538 T359657 T049540
TH	NLM (1996) US MX NL NLM (1999) CA FDA SRS (2014) USAN (1992) ES NLM (1992) INN (19XX) NLM (2013) DE AU NLM (2014) FR IE
tui	T109 T121
subClassOf	http://purl.bioontology.org/ontology/MESH/D018942

Add comment

Add proposal

Subscribe to notes emails

Delete	Subject	Author	Type	Created
No notes to display

Create mapping

Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/RCD/x02oP	RCD	CUI
http://purl.bioontology.org/ontology/RXNORM/235991	RXNORM	CUI
http://purl.bioontology.org/ontology/MSHFRE/D016559	MSHFRE	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000042009	PDQ	CUI
http://purl.bioontology.org/ontology/SCTSPA/386975001	SCTSPA	CUI
http://purl.bioontology.org/ontology/RXNORM/196463	RXNORM	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000042009	PDQ	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/1269093001	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/MSHFRE/D016559	MSHFRE	CUI
http://purl.bioontology.org/ontology/NDDF/004447	NDDF	CUI
http://purl.bioontology.org/ontology/SCTSPA/1269093001	SCTSPA	CUI
http://purl.bioontology.org/ontology/MSHFRE/D016559	MSHFRE	CUI
http://purl.bioontology.org/ontology/CSP/4004-0005	CRISP	CUI
http://purl.bioontology.org/ontology/LNC/LP15182-6	LOINC	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/109129008	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/VANDF/4020868	VANDF	CUI
http://purl.bioontology.org/ontology/RXNORM/42316	RXNORM	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000042009	PDQ	CUI
http://purl.bioontology.org/ontology/MSHFRE/D016559	MSHFRE	CUI
http://purl.bioontology.org/ontology/SCTSPA/109129008	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDDF/004446	NDDF	CUI
http://purl.bioontology.org/ontology/CSP/4004-0005	CRISP	CUI
http://purl.bioontology.org/ontology/RCD/h83..	RCD	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000007302	NDFRT	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/386975001	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/ATC/D11AH01	ATC	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148372	NDFRT	CUI
http://purl.bioontology.org/ontology/LNC/MTHU001849	LOINC	CUI
http://purl.bioontology.org/ontology/ATC/L04AD02	ATC	CUI
http://sbmi.uth.tmc.edu/ontology/ochv#15463	OCHV	LOOM
http://stirdf.jst.go.jp/id/200907057598260186	IOBC	LOOM
http://purl.bioontology.org/ontology/LNC/LP15182-6	LOINC	LOOM
http://purl.bioontology.org/ontology/VANDF/4020868	VANDF	LOOM
http://purl.bioontology.org/ontology/RXNORM/42316	RXNORM	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0085149	OCHV	LOOM
http://purl.obolibrary.org/obo/CHEBI_61049	FIDEO	LOOM
http://purl.bioontology.org/ontology/CPT/80197	CPT	LOOM
http://purl.obolibrary.org/obo/MESH_D016559	BERO	LOOM
http://purl.obolibrary.org/obo/OMIT_0017036	OMIT	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042009	PDQ	LOOM
http://www.co-ode.org/ontologies/galen#Tacrolimus	GALEN	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.540.505.810	RH-MESH	LOOM
https://go.drugbank.com/drugs/DB00864	MDM	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0519826	OCHV	LOOM
http://purl.obolibrary.org/obo/NCIT_C1311	COVID-19	LOOM
http://purl.obolibrary.org/obo/NCIT_C1311	BERO	LOOM
http://purl.bioontology.org/ontology/NDDF/004446	NDDF	LOOM
http://www.semanticweb.org/dellvostro3750/ontologies/2018/2/untitled-ontology-10#tacrolimus	HP_O	LOOM
http://www.drugbank.ca/drugs/DB00864	FTC	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017171	PMAPP-PMO	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148372	ODAE	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148372	KTAO	LOOM
https://github.com/sap218/ocimido/blob/master/ontology/ocimido.owl#OCIMIDO_00176	OCIMIDO	LOOM
http://purl.bioontology.org/ontology/RCD/h83..	RCD	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386975001	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/ATC/D11AH01	ATC	LOOM
http://bmi.utah.edu/ontologies/hfontology/C0085149	HFO	LOOM
http://doe-generated-ontology.com/OntoAD#C0085149	ONTOAD	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148372	NDFRT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D016559	RH-MESH	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311	NCIT	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU001849	LOINC	LOOM
http://purl.jp/bio/4/id/200906001249296778	IOBC	LOOM
http://purl.bioontology.org/ontology/ATC/L04AD02	ATC	LOOM