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Medical Subject Headings
Last uploaded:
March 22, 2026
| Id | http://purl.bioontology.org/ontology/MESH/D016254
http://purl.bioontology.org/ontology/MESH/D016254
|
|---|---|
| Preferred Name | Mutagenesis, Insertional |
| Definitions |
Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
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| Synonyms |
Insertional Mutagenesis
Linker-Insertion Mutagenesis
Insertion Mutations
Insertional Activations
Insertion, Gene
Linker Insertion Mutagenesis
Sequence Insertions
Insertional Mutagenesis, Viral
Gene Insertion
Insertional Activation
Insertion, Sequence
Mutagenesis, Cassette
Gene Insertions
Mutagenesis, Viral Insertional
Insertions, Gene
Insertions, Sequence
Activation, Insertional
Mutagenesis, Linker-Insertion
Mutations, Insertion
Activations, Insertional
Cassette Mutagenesis
Sequence Insertion
Viral Insertional Mutagenesis
Insertion Mutation
Mutation, Insertion
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation. |
|---|---|
| altLabel |
Insertional Mutagenesis
Linker-Insertion Mutagenesis
Insertion Mutations
Insertional Activations
Insertion, Gene
Linker Insertion Mutagenesis
Sequence Insertions
Insertional Mutagenesis, Viral
Gene Insertion
Insertional Activation
Insertion, Sequence
Mutagenesis, Cassette
Gene Insertions
Mutagenesis, Viral Insertional
Insertions, Gene
Insertions, Sequence
Activation, Insertional
Mutagenesis, Linker-Insertion
Mutations, Insertion
Activations, Insertional
Cassette Mutagenesis
Sequence Insertion
Viral Insertional Mutagenesis
Insertion Mutation
Mutation, Insertion
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| prefLabel | Mutagenesis, Insertional
|
| Machine permutation | 91
|
| HN | 91
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| type | |
| tui |
T049
T063
T045
|
| TERMUI |
T048402
T692080
T692081
T048398
T048397
T692082
T048400
T048399
T048401
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| TH |
NLM (1991)
NLM (2008)
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| MMR | 20180629
|
| notation | D016254
|
| Inverse of RO | |
| Semantic type UMLS property | |
| Inverse of AQ |
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| FX | D004251
|
| DX | 19910101
|
| cui |
C0079627
C0080314
C1955830
C1955829
C0079704
C0079868
C0079867
C1512796
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|
| DC | 1
|
| MN |
G05.365.590.575
G05.558.550
E05.393.420.601.550
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| AQL | DE EC GE HI IM IS MT PH RE SN ST
|
| MDA | 19990101
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |