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Medical Subject Headings
Last uploaded:
March 22, 2026
| Id | http://purl.bioontology.org/ontology/MESH/D016169
http://purl.bioontology.org/ontology/MESH/D016169
|
|---|---|
| Preferred Name | Lymphocyte Function-Associated Antigen-1 |
| Definitions |
An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
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| Synonyms |
Integrin alphaLbeta2
alphaLbeta2, Integrin
Antigen-1, Lymphocyte Function-Associated
LFA-1
Leukocyte Function Associated Antigen-1
Lymphocyte Function Associated Antigen 1
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1. |
|---|---|
| altLabel |
Integrin alphaLbeta2
alphaLbeta2, Integrin
Antigen-1, Lymphocyte Function-Associated
LFA-1
Leukocyte Function Associated Antigen-1
Lymphocyte Function Associated Antigen 1
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| prefLabel | Lymphocyte Function-Associated Antigen-1
|
| Machine permutation | 1991
|
| HN | 1991
|
| type | |
| tui |
T116
T129
T192
|
| TERMUI |
T048009
T048010
T048012
T048011
|
| TH |
NLM (1997)
NLM (1991)
|
| MMR | 20230316
|
| notation | D016169
|
| Inverse of RO | |
| Semantic type UMLS property | |
| Inverse of AQ |
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|
| DX | 19910101
|
| cui | C0079717
|
| DC | 1
|
| MN |
D23.050.301.350.074.400
D12.776.543.550.200.625.550
D09.400.430.890.200.625.550
D12.776.543.750.705.877.550
D12.776.395.550.200.074.937
D12.776.543.750.705.408.600.400
D12.776.543.550.200.093.937
D09.400.430.890.200.074.937
D23.050.301.350.625.550
D12.776.395.550.200.625.550
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|
| AQL | AD AE AN BI BL CF CH CL DE EC GE HI IM IP ME PD PH PO RE TO TU UL UR
|
| Inverse of RB | 0
|
| MDA | 19990101
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |