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Last uploaded: January 31, 2024

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Preferred Name	Tumor Necrosis Factor-alpha
Synonyms	TNF-alpha Cachectin Tumor Necrosis Factor TNFalpha Cachectin-Tumor Necrosis Factor Tumor Necrosis Factor alpha Tumor Necrosis Factor Ligand Superfamily Member 2 Tumor Necrosis Factor Cachectin TNF Superfamily, Member 2
Definitions	Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
ID	http://purl.bioontology.org/ontology/MESH/D014409
altLabel	TNF-alpha Cachectin Tumor Necrosis Factor TNFalpha Cachectin-Tumor Necrosis Factor Tumor Necrosis Factor alpha Tumor Necrosis Factor Ligand Superfamily Member 2 Tumor Necrosis Factor Cachectin TNF Superfamily, Member 2
AQL	AD AE AG AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
cui	C1456820
DC	1
definition	Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
DX	19880101
FX	D000068879 D000068582 D000069285
HN	2005(1988)
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	0
Inverse of RO	http://purl.bioontology.org/ontology/MESH/D000069285 http://purl.bioontology.org/ontology/MESH/D000068582 http://purl.bioontology.org/ontology/MESH/D015275 http://purl.bioontology.org/ontology/MESH/D000068879 http://purl.bioontology.org/ontology/MESH/D009336
Machine permutation	2005; see TUMOR NECROSIS FACTOR 1988-2005
Mapped from	http://purl.bioontology.org/ontology/MESH/C079336 http://purl.bioontology.org/ontology/MESH/C000630923 http://purl.bioontology.org/ontology/MESH/C061153 http://purl.bioontology.org/ontology/MESH/C097260 http://purl.bioontology.org/ontology/MESH/C109083 http://purl.bioontology.org/ontology/MESH/C464840 http://purl.bioontology.org/ontology/MESH/C076419 http://purl.bioontology.org/ontology/MESH/C439524 http://purl.bioontology.org/ontology/MESH/C105965 http://purl.bioontology.org/ontology/MESH/C523999 http://purl.bioontology.org/ontology/MESH/C111999 http://purl.bioontology.org/ontology/MESH/C066650 http://purl.bioontology.org/ontology/MESH/C411348 http://purl.bioontology.org/ontology/MESH/C411347 http://purl.bioontology.org/ontology/MESH/C098256 http://purl.bioontology.org/ontology/MESH/C464839 http://purl.bioontology.org/ontology/MESH/C448904 http://purl.bioontology.org/ontology/MESH/C448905 http://purl.bioontology.org/ontology/MESH/C112561 http://purl.bioontology.org/ontology/MESH/C117771 http://purl.bioontology.org/ontology/MESH/C460220 http://purl.bioontology.org/ontology/MESH/C540591 http://purl.bioontology.org/ontology/MESH/C471050 http://purl.bioontology.org/ontology/MESH/C092033 http://purl.bioontology.org/ontology/MESH/C109186 http://purl.bioontology.org/ontology/MESH/C096504 http://purl.bioontology.org/ontology/MESH/C109426 http://purl.bioontology.org/ontology/MESH/C109425
MDA	19870508
MMR	20230316
MN	D12.776.124.900 D23.529.374.500.800 D12.644.276.374.500.800 D12.776.467.374.750.626 D09.400.430.965 D12.776.467.374.500.800 D12.776.395.930 D23.529.374.750.626 D12.644.276.374.750.626
notation	D014409
prefLabel	Tumor Necrosis Factor-alpha
TERMUI	T042152 T661558 T042150 T042154 T716352 T042151 T042153 T660224
TH	NLM (2009) UNK (19XX) NLM (1988) NLM (2007)
tui	T116 T129
subClassOf	http://purl.bioontology.org/ontology/MESH/D048069 http://purl.bioontology.org/ontology/MESH/D006023 http://purl.bioontology.org/ontology/MESH/D015846 http://purl.bioontology.org/ontology/MESH/D001798

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/MSHFRE/D014409	MSHFRE	CUI
http://purl.bioontology.org/ontology/SCTSPA/39525005	SCTSPA	CUI
http://purl.bioontology.org/ontology/CSP/1553-6966	CRISP	CUI
http://purl.bioontology.org/ontology/SCTSPA/8612007	SCTSPA	CUI
http://purl.bioontology.org/ontology/LNC/LP18480-1	LOINC	CUI
http://purl.bioontology.org/ontology/LNC/MTHU004497	LOINC	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000043225	PDQ	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/8612007	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/39525005	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000170420	NDFRT	CUI
http://purl.bioontology.org/ontology/SNMI/F-CB960	SNMI	CUI
http://purl.bioontology.org/ontology/SNMI/F-CB962	SNMI	CUI
http://www.ebi.ac.uk/efo/EFO_0003271	EFO	LOOM
http://doe-generated-ontology.com/OntoAD#C1456820	ONTOAD	LOOM
http://www.ebi.ac.uk/efo/EFO_0003271	BMONT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.467.972.626	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.276.374.500.800	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014409	RH-MESH	LOOM
http://purl.bioontology.org/ontology/CSP/1553-6966	CRISP	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.276.374.750.626	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.395.930	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D23.529.972.626	RH-MESH	LOOM
http://purl.bioontology.org/ontology/LNC/LP18480-1	LOINC	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004497	LOINC	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000043225	PDQ	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.124.900	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D23.529.374.750.626	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.467.374.500.800	RH-MESH	LOOM
http://ccdb.ucsd.edu/SAO/1.2#sao220868685	SAO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.276.972.626	RH-MESH	LOOM
http://purl.obolibrary.org/obo/IDOMAL_0000783	IDOMAL	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/39525005	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/SNMI/F-CB962	SNMI	LOOM
http://purl.obolibrary.org/obo/OMIT_0015245	OMIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D23.529.374.500.800	RH-MESH	LOOM
http://purl.obolibrary.org/obo/MESH_D014409	BERO	LOOM
http://www.case.edu/ProvCaRe/provcare#TumorNecrosisFactorAlpha	NEUROBRG	LOOM
http://scai.fraunhofer.de/MSOntology#Tumor_Necrosis_Factor_Alpha	MSO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.467.374.750.626	RH-MESH	LOOM
http://id.nlm.nih.gov/mesh/D014409	MDM	LOOM
http://purl.obolibrary.org/obo/PR_000000134	NIFSTD	LOOM
http://purl.obolibrary.org/obo/PR_000000134	IDODEN	LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_7875f576_c548_4d5d_b40d_bc0188025177	STO-DRAFT	LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_7875f576_c548_4d5d_b40d_bc0188025177	CVAO	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00021544	PMAPP-PMO	LOOM
http://uri.neuinfo.org/nif/nifstd/sao220868685	NIFSTD	LOOM
http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571345044435365949	ACVD_ONTOLOGY	LOOM