Medical Subject Headings

Last uploaded: March 22, 2026
Id http://purl.bioontology.org/ontology/MESH/D013254
http://purl.bioontology.org/ontology/MESH/D013254
Preferred Name

Steroid 17-alpha-Hydroxylase
Definitions
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
Synonyms
17-alpha-Hydroxylase, Steroid
Aldolase, 17 alpha-Hydroxyprogesterone
Aldolase, Hydroxyprogesterone
Cytochrome P-450(17-alpha)
Steroid 17 Monooxygenase
Hydroxyprogesterone Aldolase
Steroid 17 alpha Hydroxylase
Cytochrome P-450(17 alpha)
CYP17
17 alpha-Hydroxylase Cytochrome P-450
P450(c17)
17,20 Desmolase
17,20-Desmolase
Steroid 17 Hydroxylase
17,20 Lyase
17 alpha Hydroxylase Cytochrome P 450
17 alpha-Hydroxylase, Steroid
alpha-Hydroxyprogesterone Aldolase, 17
Steroid 17-Hydroxylase
17 alpha-Hydroxyprogesterone Aldolase
17,20-Lyase
Steroid 17-Monooxygenase
Steroid 17 alpha-Monooxygenase
Steroid-17-Hydroxylase
17 alpha-Monooxygenase, Steroid
Cytochrome P450(17 alpha)
17 alpha Hydroxylase
17-Monooxygenase, Steroid
Steroid 17 alpha-Hydroxylase
17 alpha Hydroxyprogesterone Aldolase
17 alpha-Hydroxylase
Steroid 17 alpha Monooxygenase
17-Hydroxylase, Steroid
Steroid, hydrogen-donor:oxygen oxidoreductase (17 alpha-hydroxylating)
alpha-Monooxygenase, Steroid 17
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Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
altLabel
17-alpha-Hydroxylase, Steroid
Aldolase, 17 alpha-Hydroxyprogesterone
Aldolase, Hydroxyprogesterone
Cytochrome P-450(17-alpha)
Steroid 17 Monooxygenase
Hydroxyprogesterone Aldolase
Steroid 17 alpha Hydroxylase
Cytochrome P-450(17 alpha)
CYP17
17 alpha-Hydroxylase Cytochrome P-450
P450(c17)
17,20 Desmolase
17,20-Desmolase
Steroid 17 Hydroxylase
17,20 Lyase
17 alpha Hydroxylase Cytochrome P 450
17 alpha-Hydroxylase, Steroid
alpha-Hydroxyprogesterone Aldolase, 17
Steroid 17-Hydroxylase
17 alpha-Hydroxyprogesterone Aldolase
17,20-Lyase
Steroid 17-Monooxygenase
Steroid 17 alpha-Monooxygenase
Steroid-17-Hydroxylase
17 alpha-Monooxygenase, Steroid
Cytochrome P450(17 alpha)
17 alpha Hydroxylase
17-Monooxygenase, Steroid
Steroid 17 alpha-Hydroxylase
17 alpha Hydroxyprogesterone Aldolase
17 alpha-Hydroxylase
Steroid 17 alpha Monooxygenase
17-Hydroxylase, Steroid
Steroid, hydrogen-donor:oxygen oxidoreductase (17 alpha-hydroxylating)
alpha-Monooxygenase, Steroid 17
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prefLabel
Steroid 17-alpha-Hydroxylase
EC
deficiency:Adrenal Hyperplasia, Congenital
Machine permutation
2003; see STEROID 17 ALPHA-MONOOXYGENASE 1997-2002, see STEROID 17-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1990; for STEROID-17-HYDROXYLASE see STEROID HYDROXYLASES 1978-1989; for 17,20-LYASE see 17 ALPHA-HYDROXYPROGESTERONE ALDOLASE 1996-1997
HN
2003 (1978)
Mapped from
type
tui
T116
T126
TERMUI
T494562
T038954
T108454
T038957
T038956
T057864
T038953
T038961
T038959
T038955
T038952
T038950
T038962
T038958
T038951
T057865
T038960
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TH
NLM (1997)
NLM (1990)
NLM (1978)
UNK (19XX)
NLM (2003)
NLM (1998)
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MMR
20160601
notation
D013254
Inverse of RO
Semantic type UMLS property
RR
9029-67-8 (CAS RN)
62213-24-5 (CAS RN)
Inverse of AQ
http://purl.bioontology.org/ontology/MESH/Q000097
http://purl.bioontology.org/ontology/MESH/Q000096
http://purl.bioontology.org/ontology/MESH/Q000627
http://purl.bioontology.org/ontology/MESH/Q000648
http://purl.bioontology.org/ontology/MESH/Q000493
http://purl.bioontology.org/ontology/MESH/Q000494
http://purl.bioontology.org/ontology/MESH/Q000276
http://purl.bioontology.org/ontology/MESH/Q000138
http://purl.bioontology.org/ontology/MESH/Q000134
http://purl.bioontology.org/ontology/MESH/Q000266
http://purl.bioontology.org/ontology/MESH/Q000378
http://purl.bioontology.org/ontology/MESH/Q000008
http://purl.bioontology.org/ontology/MESH/Q000009
http://purl.bioontology.org/ontology/MESH/Q000032
http://purl.bioontology.org/ontology/MESH/Q000037
http://purl.bioontology.org/ontology/MESH/Q000191
http://purl.bioontology.org/ontology/MESH/Q000302
http://purl.bioontology.org/ontology/MESH/Q000145
http://purl.bioontology.org/ontology/MESH/Q000592
http://purl.bioontology.org/ontology/MESH/Q000737
http://purl.bioontology.org/ontology/MESH/Q000502
http://purl.bioontology.org/ontology/MESH/Q000506
http://purl.bioontology.org/ontology/MESH/Q000187
http://purl.bioontology.org/ontology/MESH/Q000235
http://purl.bioontology.org/ontology/MESH/Q000633
http://purl.bioontology.org/ontology/MESH/Q000600
http://purl.bioontology.org/ontology/MESH/Q000652
http://purl.bioontology.org/ontology/MESH/Q000528
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FX
D000312
DX
19910101
cui
C0044970
C0038302
DC
1
MN
D08.811.682.690.708.170.444.500
D08.811.682.690.708.170.915.748
D08.244.453.487.500
D08.244.453.915.748
D12.776.422.220.453.487.500
D12.776.422.220.453.915.748
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AQL
AD AE AI AN BI BL CF CH CL CS DE EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
Inverse of RB
EC 1.14.14.19
0
MDA
20020520
subClassOf
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