Medical Subject Headings

Last uploaded: August 28, 2024

Preferred Name	Farnesyl-Diphosphate Farnesyltransferase
Synonyms	Farnesyldiphosphate-Farnesyldiphosphate Farnesyltransferase Presqualene-Diphosphate Synthase Synthase, Squalene Transferase, FPP-FPP Farnesyl Squalene Synthase Farnesyldiphosphate Farnesyldiphosphate Farnesyltransferase Farnesyltransferase, Farnesyldiphosphate-Farnesyldiphosphate Squalene Synthetase FPP-FPP Farnesyl Transferase Farnesyl Diphosphate Farnesyltransferase Farnesyltransferase, Farnesyl-Diphosphate Farnesyl Transferase, FPP-FPP Presqualene Diphosphate Synthase Synthetase, Squalene Synthase, Presqualene-Diphosphate FPP FPP Farnesyl Transferase
Definitions	The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway.
ID	http://purl.bioontology.org/ontology/MESH/D013186
altLabel	Farnesyldiphosphate-Farnesyldiphosphate Farnesyltransferase Presqualene-Diphosphate Synthase Synthase, Squalene Transferase, FPP-FPP Farnesyl Squalene Synthase Farnesyldiphosphate Farnesyldiphosphate Farnesyltransferase Farnesyltransferase, Farnesyldiphosphate-Farnesyldiphosphate Squalene Synthetase FPP-FPP Farnesyl Transferase Farnesyl Diphosphate Farnesyltransferase Farnesyltransferase, Farnesyl-Diphosphate Farnesyl Transferase, FPP-FPP Presqualene Diphosphate Synthase Synthetase, Squalene Synthase, Presqualene-Diphosphate FPP FPP Farnesyl Transferase
AQL	AD AE AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
cui	C0597790
DC	1
definition	The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway.
DX	19910101
HN	2006(1975)
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	EC 2.5.1.21
Machine permutation	2006; see OXIDOREDUCTASES 1975-1990; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE was indexed under OXIDOREDUCTASES & SQUALENE SYNTHETASE 1998-2001
Mapped from	http://purl.bioontology.org/ontology/MESH/C091056 http://purl.bioontology.org/ontology/MESH/C496127
MDA	19741119
MMR	20090713
MN	D08.811.913.225.431
notation	D013186
prefLabel	Farnesyl-Diphosphate Farnesyltransferase
TERMUI	T327172 T327171 T327174 T528461 T038733 T327173
TH	NLM (2004) NLM (1975) NLM (2006)
tui	T116 T126
subClassOf	http://purl.bioontology.org/ontology/MESH/D019883

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/CSP/2955-6564	CRISP	CUI
http://purl.bioontology.org/ontology/MSHFRE/D013186	MSHFRE	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000168314	NDFRT	CUI
http://purl.bioontology.org/ontology/CSP/2955-6564	CRISP	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/13230006	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/SCTSPA/13230006	SCTSPA	CUI
http://purl.bioontology.org/ontology/SNMI/F-68D48	SNMI	CUI
http://www.phoc.org.cn/pmo/class/PMO_00020828	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/MESH_D013186	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013186	RH-MESH	LOOM
http://id.nlm.nih.gov/mesh/D013186	MDM	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.811.913.225.431	RH-MESH	LOOM
http://purl.obolibrary.org/obo/OMIT_0014065	OMIT	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/13230006	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/SNMI/F-68D48	SNMI	LOOM