loading...| Preferred Name |
Receptors, LDL |
|
| Synonyms |
Lipoprotein LDL Receptors Receptors, Lipoprotein LDL |
|
| Definitions |
Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D011973 |
|
| altLabel |
Lipoprotein LDL Receptors Receptor, LDL Low Density Lipoprotein Receptor Receptors, Low Density Lipoprotein LDL Receptors, Lipoprotein LDL Receptors Receptors, Lipoprotein, LDL Low Density Lipoprotein Receptors LDL Receptor Receptors, Lipoprotein LDL |
|
| AQL |
AD AG AI AN BI BL CH CL DE DF GE HI IM IP ME PH RE TU UL |
|
| cui |
C0034821 |
|
| DC |
1 |
|
| definition |
Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking. |
|
| DX |
19850101 |
|
| FX |
D008077 |
|
| HN |
85; LIPOPROTEINS, LDL RECEPTORS was see RECEPTORS, LDL 1985-92 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000187 |
|
| Inverse of RB |
0 |
|
| Inverse of RO | ||
| Machine permutation |
85; LIPOPROTEINS, LDL RECEPTORS was see RECEPTORS, LDL 1985-92 |
|
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C506800 http://purl.bioontology.org/ontology/MESH/C085992 http://purl.bioontology.org/ontology/MESH/C561588 http://purl.bioontology.org/ontology/MESH/C434476 http://purl.bioontology.org/ontology/MESH/C539830 http://purl.bioontology.org/ontology/MESH/C036053 http://purl.bioontology.org/ontology/MESH/C573412 http://purl.bioontology.org/ontology/MESH/C491168 http://purl.bioontology.org/ontology/MESH/C491167 http://purl.bioontology.org/ontology/MESH/C027656 http://purl.bioontology.org/ontology/MESH/C575907 http://purl.bioontology.org/ontology/MESH/C525701 http://purl.bioontology.org/ontology/MESH/C578534 http://purl.bioontology.org/ontology/MESH/C503871 http://purl.bioontology.org/ontology/MESH/C540760 http://purl.bioontology.org/ontology/MESH/C486644 http://purl.bioontology.org/ontology/MESH/C549679 |
|
| MDA |
19840525 |
|
| MMR |
20060705 |
|
| MN |
D12.776.543.750.710.450 |
|
| notation |
D011973 |
|
| OL |
use RECEPTORS, LDL to search LIPOPROTEINS, LDL RECEPTORS 1985-92 |
|
| prefLabel |
Receptors, LDL |
|
| TERMUI |
T035534 T035535 T035533 T035537 T035539 T035541 T035536 T035538 T035540 |
|
| TH |
NLM (1993) NLM (1994) UNK (19XX) NLM (1985) |
|
| tui |
T116 T192 |
|
| subClassOf |