Medical Subject Headings

Last uploaded: March 22, 2026

Id	http://purl.bioontology.org/ontology/MESH/D011770 http://purl.bioontology.org/ontology/MESH/D011770
Preferred Name	Pyruvate Kinase
Definitions	ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC 2.7.1.40.
Synonyms	M2-Type Pyruvate Kinase Pyruvate Kinase L Pyruvate Kinase, M1-Type R Type Pyruvate Kinase L-Type Pyruvate Kinase M1 Type Pyruvate Kinase R-Type Pyruvate Kinase M-Type Pyruvate Kinase Pyruvate Kinase, L-Type L Type Pyruvate Kinase M Type Pyruvate Kinase M2 Type Pyruvate Kinase M1-Type Pyruvate Kinase Pyruvate Kinase, R-Type Pyruvate Kinase, M2-Type Pyruvate Kinase, M-Type See more See less
Type	http://www.w3.org/2002/07/owl#Class

definition	ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC 2.7.1.40.
altLabel	M2-Type Pyruvate Kinase Pyruvate Kinase L Pyruvate Kinase, M1-Type R Type Pyruvate Kinase L-Type Pyruvate Kinase M1 Type Pyruvate Kinase R-Type Pyruvate Kinase M-Type Pyruvate Kinase Pyruvate Kinase, L-Type L Type Pyruvate Kinase M Type Pyruvate Kinase M2 Type Pyruvate Kinase M1-Type Pyruvate Kinase Pyruvate Kinase, R-Type Pyruvate Kinase, M2-Type Pyruvate Kinase, M-Type See more See less
prefLabel	Pyruvate Kinase
Machine permutation	65
HN	65
Mapped from	http://purl.bioontology.org/ontology/MESH/C000728078 http://purl.bioontology.org/ontology/MESH/C000628218 http://purl.bioontology.org/ontology/MESH/C000720670 http://purl.bioontology.org/ontology/MESH/C412008 http://purl.bioontology.org/ontology/MESH/C564858 http://purl.bioontology.org/ontology/MESH/C000630371 http://purl.bioontology.org/ontology/MESH/C000633144 http://purl.bioontology.org/ontology/MESH/C000624223 See more See less
type	http://www.w3.org/2002/07/owl#Class
tui	T116 T126
TERMUI	T034794 T034790 T034793 T034795 T034791 T034789 T034792 See more See less
TH	NLM (1965) NLM (1991) UNK (19XX)
MMR	20030709
notation	D011770
Inverse of RO	http://purl.bioontology.org/ontology/MESH/D000743
Semantic type UMLS property	http://purl.bioontology.org/ontology/STY/T126 http://purl.bioontology.org/ontology/STY/T116
RR	9001-59-6 (CAS RN)
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528 See more See less
FX	D000743
DX	19650101
cui	C0079782 C0079780 C0034349 C0079781 C0080075 C0034348 See more See less
DC	1
MN	D08.811.913.696.620.695
AN	do not coord L-, R-, M-, M1- or M2-type pyruvate kinase with ISOENZYMES
AQL	AD AE AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
Inverse of RB	EC 2.7.1.40 0
MDA	19990101
subClassOf	http://purl.bioontology.org/ontology/MESH/D017853

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