Medical Subject Headings

Last uploaded: August 28, 2024

Preferred Name	Transglutaminases
Synonyms	Transglutaminase Glutaminyl Peptide Gamma Glutamyltransferases Glutaminyl-Peptide Gamma-Glutamyltransferases Protein-Glutamine gamma-Glutamyltransferases gamma-Glutamyltransferases, Protein-Glutamine Protein Glutamine gamma Glutamyltransferases Gamma-Glutamyltransferases, Glutaminyl-Peptide Protein-glutamine:amine gamma-glutamyltransferase
Definitions	Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.
ID	http://purl.bioontology.org/ontology/MESH/D011503
altLabel	Transglutaminase Glutaminyl Peptide Gamma Glutamyltransferases Glutaminyl-Peptide Gamma-Glutamyltransferases Protein-Glutamine gamma-Glutamyltransferases gamma-Glutamyltransferases, Protein-Glutamine Protein Glutamine gamma Glutamyltransferases Gamma-Glutamyltransferases, Glutaminyl-Peptide Protein-glutamine:amine gamma-glutamyltransferase
AN	distinguish entry terms GLUTAMINYL-PEPTIDE GAMMA-GLUTAMYLTRANSFERASES, and TRANSGLUTAMINASES from GAMMA-GLUTAMYL TRANSPEPTIDASE which is involved with glutathione metabolism; PLASMA TRANSGLUTAMINASE see FACTOR XIIIA is also available
AQL	AD AE AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
cui	C0033679
DC	1
definition	Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.
DX	19860101
HN	2002(1986)
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	EC 2.3.2.13
Machine permutation	2002; see PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 1986-2002; for TRANSGLUTAMINASES see TRANSGLUTAMINASES 1986-2002
Mapped from	http://purl.bioontology.org/ontology/MESH/C105804 http://purl.bioontology.org/ontology/MESH/C532312 http://purl.bioontology.org/ontology/MESH/C498713 http://purl.bioontology.org/ontology/MESH/C498712 http://purl.bioontology.org/ontology/MESH/C117784 http://purl.bioontology.org/ontology/MESH/C117785 http://purl.bioontology.org/ontology/MESH/C082463 http://purl.bioontology.org/ontology/MESH/C060969 http://purl.bioontology.org/ontology/MESH/C527821 http://purl.bioontology.org/ontology/MESH/C000625929 http://purl.bioontology.org/ontology/MESH/C532876 http://purl.bioontology.org/ontology/MESH/C418702 http://purl.bioontology.org/ontology/MESH/C418703
MDA	19850424
MMR	20200527
MN	D08.811.913.050.200.800
notation	D011503
prefLabel	Transglutaminases
RR	80146-85-6 (CAS RN)
TERMUI	T000999603 T033989 T033990 T033991
TH	UNK (19XX) NLM (2021) NLM (1986)
tui	T116 T126
subClassOf	http://purl.bioontology.org/ontology/MESH/D019881

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/CSP/0125-3973	CRISP	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/36231008	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/SCTSPA/36231008	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000168159	NDFRT	CUI
http://purl.bioontology.org/ontology/MSHFRE/D011503	MSHFRE	CUI
http://purl.bioontology.org/ontology/SNMI/F-68720	SNMI	CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011503	RH-MESH	LOOM
http://purl.obolibrary.org/obo/MESH_D011503	BERO	LOOM
http://id.nlm.nih.gov/mesh/D011503	MDM	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00020409	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/OMIT_0012447	OMIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.811.913.050.200.800	RH-MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#10247	OCHV	LOOM