Medical Subject Headings

Last uploaded: March 22, 2026

Id	http://purl.bioontology.org/ontology/MESH/D011493 http://purl.bioontology.org/ontology/MESH/D011493
Preferred Name	Protein Kinase C
Definitions	An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
Synonyms	Phospholipid Sensitive Calcium Dependent Protein Kinase Phospholipid-Dependent Kinase, Calcium-Activated PKC Serine Threonine Kinase Calcium Phospholipid-Dependent Protein Kinase Protein Kinase M Calcium Phospholipid Dependent Protein Kinase Phospholipid-Sensitive Calcium-Dependent Protein Kinase Calcium Activated Phospholipid Dependent Kinase PKC Serine-Threonine Kinase Calcium-Activated Phospholipid-Dependent Kinase Serine-Threonine Kinase, PKC See more See less
Type	http://www.w3.org/2002/07/owl#Class

definition	An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
altLabel	Phospholipid Sensitive Calcium Dependent Protein Kinase Phospholipid-Dependent Kinase, Calcium-Activated PKC Serine Threonine Kinase Calcium Phospholipid-Dependent Protein Kinase Protein Kinase M Calcium Phospholipid Dependent Protein Kinase Phospholipid-Sensitive Calcium-Dependent Protein Kinase Calcium Activated Phospholipid Dependent Kinase PKC Serine-Threonine Kinase Calcium-Activated Phospholipid-Dependent Kinase Serine-Threonine Kinase, PKC See more See less
prefLabel	Protein Kinase C
Machine permutation	86; CALCIUM PHOSPHOLIPID-DEPENDENT PROTEIN KINASE was CALCIUM-PHOSPHOLIPID DEPENDENT PROTEIN KINASE 1986-93
HN	86; CALCIUM PHOSPHOLIPID-DEPENDENT PROTEIN KINASE was CALCIUM-PHOSPHOLIPID DEPENDENT PROTEIN KINASE 1986-93
Mapped from	http://purl.bioontology.org/ontology/MESH/C000708935 http://purl.bioontology.org/ontology/MESH/C087857 http://purl.bioontology.org/ontology/MESH/C504730 http://purl.bioontology.org/ontology/MESH/C119190 http://purl.bioontology.org/ontology/MESH/C484814 http://purl.bioontology.org/ontology/MESH/C115197 http://purl.bioontology.org/ontology/MESH/C103744 http://purl.bioontology.org/ontology/MESH/C115015 http://purl.bioontology.org/ontology/MESH/C121046 http://purl.bioontology.org/ontology/MESH/C073885 http://purl.bioontology.org/ontology/MESH/C490702 http://purl.bioontology.org/ontology/MESH/C524695 http://purl.bioontology.org/ontology/MESH/C000634148 http://purl.bioontology.org/ontology/MESH/C097994 http://purl.bioontology.org/ontology/MESH/C097993 http://purl.bioontology.org/ontology/MESH/C000730208 http://purl.bioontology.org/ontology/MESH/C072093 http://purl.bioontology.org/ontology/MESH/C576752 http://purl.bioontology.org/ontology/MESH/C061570 http://purl.bioontology.org/ontology/MESH/C511267 http://purl.bioontology.org/ontology/MESH/C576769 http://purl.bioontology.org/ontology/MESH/C081975 http://purl.bioontology.org/ontology/MESH/C488488 http://purl.bioontology.org/ontology/MESH/C000708940 http://purl.bioontology.org/ontology/MESH/C000720325 http://purl.bioontology.org/ontology/MESH/C089212 http://purl.bioontology.org/ontology/MESH/C579820 http://purl.bioontology.org/ontology/MESH/C104969 http://purl.bioontology.org/ontology/MESH/C532584 http://purl.bioontology.org/ontology/MESH/C027776 See more See less
type	http://www.w3.org/2002/07/owl#Class
tui	T116 T126
TERMUI	T033940 T033942 T033941 T033939 T033944 T637820 See more See less
TH	UNK (19XX) NLM (1986) NLM (2006)
MMR	20210521
notation	D011493
Semantic type UMLS property	http://purl.bioontology.org/ontology/STY/T126 http://purl.bioontology.org/ontology/STY/T116
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528 See more See less
DX	19860101
cui	C0033634 C0033638
DC	1
MN	D08.811.913.696.620.682.700.725 D12.776.476.563.725
AQL	AD AE AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
Inverse of RB	EC 2.7.11.13 0
MDA	19990101
subClassOf	http://purl.bioontology.org/ontology/MESH/D017346

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