Medical Subject Headings

Last uploaded: March 22, 2026

Id	http://purl.bioontology.org/ontology/MESH/D010959 http://purl.bioontology.org/ontology/MESH/D010959
Preferred Name	Tissue Plasminogen Activator
Definitions	A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
Synonyms	Activase Plasminogen Activator, Tissue-Type Lysatec rt-PA Tissue Activator D-44 Lysatec rt PA Plasminogen Activator, Tissue Tisokinase Alteplase Lysatec rtPA T-Plasminogen Activator TTPA Tissue Type Plasminogen Activator Tissue Activator D 44 Plasminogen Activator, Tissue Type T Plasminogen Activator Actilyse Tissue-Type Plasminogen Activator See more See less
Type	http://www.w3.org/2002/07/owl#Class

definition	A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
altLabel	Activase Plasminogen Activator, Tissue-Type Lysatec rt-PA Tissue Activator D-44 Lysatec rt PA Plasminogen Activator, Tissue Tisokinase Alteplase Lysatec rtPA T-Plasminogen Activator TTPA Tissue Type Plasminogen Activator Tissue Activator D 44 Plasminogen Activator, Tissue Type T Plasminogen Activator Actilyse Tissue-Type Plasminogen Activator See more See less
prefLabel	Tissue Plasminogen Activator
Machine permutation	98; see ALTEPLASE 1992-97; see PLASMINOGEN ACTIVATOR, TISSUE-TYPE 1986-91
HN	98(86)
Mapped from	http://purl.bioontology.org/ontology/MESH/C067262 http://purl.bioontology.org/ontology/MESH/C081981 http://purl.bioontology.org/ontology/MESH/C083865 http://purl.bioontology.org/ontology/MESH/C083866 http://purl.bioontology.org/ontology/MESH/C567341 http://purl.bioontology.org/ontology/MESH/C072781 http://purl.bioontology.org/ontology/MESH/C059835 http://purl.bioontology.org/ontology/MESH/C550736 http://purl.bioontology.org/ontology/MESH/C087896 http://purl.bioontology.org/ontology/MESH/C068645 http://purl.bioontology.org/ontology/MESH/C065621 http://purl.bioontology.org/ontology/MESH/C104096 http://purl.bioontology.org/ontology/MESH/C085027 http://purl.bioontology.org/ontology/MESH/C449559 http://purl.bioontology.org/ontology/MESH/C080391 http://purl.bioontology.org/ontology/MESH/C089949 http://purl.bioontology.org/ontology/MESH/C473928 http://purl.bioontology.org/ontology/MESH/C077412 http://purl.bioontology.org/ontology/MESH/C065736 See more See less
type	http://www.w3.org/2002/07/owl#Class
isa	http://purl.bioontology.org/ontology/MESH/D005343
PA	D005343
tui	T116 T126 T121
TERMUI	T707756 T032269 T032270 T032272 T365869 T032267 T032271 T032266 T505964 T032273 T032268 See more See less
TH	US MX NLM (2009) UK NLM (2000) NL NLM (1999) CA JAN (19XX) ES NLM (1992) UNK (19XX) INN (19XX) DE AU NLM (1998) BAN (19XX) USAN (1989) IE See more See less
MMR	20160701
notation	D010959
Semantic type UMLS property	http://purl.bioontology.org/ontology/STY/T126 http://purl.bioontology.org/ontology/STY/T121 http://purl.bioontology.org/ontology/STY/T116
RR	105857-23-6 (Alteplase)
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528 See more See less
DX	19860101
cui	C0032143 C0678113 C0701942
DC	1
MN	D08.811.277.656.959.350.875 D12.776.124.125.662.768 D23.119.970 D08.811.277.656.300.760.875
LT	TRD
AQL	AD AE AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
Inverse of RB	EC 3.4.21.68 0
MDA	19990101
subClassOf	http://purl.bioontology.org/ontology/MESH/D012697 http://purl.bioontology.org/ontology/MESH/D001779 http://purl.bioontology.org/ontology/MESH/D010960

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