Medical Subject Headings

Last uploaded: January 16, 2025

Id	http://purl.bioontology.org/ontology/MESH/D009569 http://purl.bioontology.org/ontology/MESH/D009569
Preferred Name	Nitric Oxide
Definitions	A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Synonyms	Nitrogen oxide (NO) Endogenous Nitrate Vasodilator Vasodilator, Endogenous Nitrate Oxide, Nitric Monoxide, Nitrogen Nitric Oxide, Endothelium Derived Endothelium-Derived Nitric Oxide Nitrogen Monoxide Nitrate Vasodilator, Endogenous Nitric Oxide, Endothelium-Derived Monoxide, Mononitrogen Mononitrogen Monoxide See more See less
Type	http://www.w3.org/2002/07/owl#Class

definition	A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
altLabel	Nitrogen oxide (NO) Endogenous Nitrate Vasodilator Vasodilator, Endogenous Nitrate Oxide, Nitric Monoxide, Nitrogen Nitric Oxide, Endothelium Derived Endothelium-Derived Nitric Oxide Nitrogen Monoxide Nitrate Vasodilator, Endogenous Nitric Oxide, Endothelium-Derived Monoxide, Mononitrogen Mononitrogen Monoxide See more See less
prefLabel	Nitric Oxide
TH	NLM (1965) NLM (1999) NLM (1990) FDA SRS (2014) NLM (1994) UNK (19XX) USAN (19XX) See more See less
notation	D009569
RR	10102-43-9 (Nitric Oxide)
DX	19650101
Machine permutation	1965
MN	D01.625.700.500 D01.625.550.500 D01.339.409.500 D01.650.550.587.600 D02.389.508.500
PA	D064426 D001993 D016166 D018377 D045462
FX	D000089142 D045462 D020030
MMR	20230226
Mapped from	http://purl.bioontology.org/ontology/MESH/C088437 http://purl.bioontology.org/ontology/MESH/C058377 http://purl.bioontology.org/ontology/MESH/C000594696 http://purl.bioontology.org/ontology/MESH/C112653 http://purl.bioontology.org/ontology/MESH/C504137 http://purl.bioontology.org/ontology/MESH/C000634368 http://purl.bioontology.org/ontology/MESH/C498979 http://purl.bioontology.org/ontology/MESH/C544422 http://purl.bioontology.org/ontology/MESH/C110153 http://purl.bioontology.org/ontology/MESH/C110152 http://purl.bioontology.org/ontology/MESH/C093551 http://purl.bioontology.org/ontology/MESH/C000596989 http://purl.bioontology.org/ontology/MESH/C106536 See more See less
AQL	AA AD AE AG AI AN BI BL CF CH CL CS DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UR
HN	1965
subClassOf	http://purl.bioontology.org/ontology/MESH/D009589 http://purl.bioontology.org/ontology/MESH/D026361
Semantic type UMLS property	http://purl.bioontology.org/ontology/STY/T121 http://purl.bioontology.org/ontology/STY/T197
Inverse of RB	31C4KY9ESH
DC	1
MDA	19990101
Inverse of RO	http://purl.bioontology.org/ontology/MESH/D000089142 http://purl.bioontology.org/ontology/MESH/D020030 http://purl.bioontology.org/ontology/MESH/D045462
type	http://www.w3.org/2002/07/owl#Class
tui	T197 T121
cui	C0028128
isa	http://purl.bioontology.org/ontology/MESH/D018377 http://purl.bioontology.org/ontology/MESH/D016166 http://purl.bioontology.org/ontology/MESH/D045462 http://purl.bioontology.org/ontology/MESH/D001993 http://purl.bioontology.org/ontology/MESH/D064426
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528 See more See less
TERMUI	T028508 T046281 T028510 T046285 T028507

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