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Medical Subject Headings
Last uploaded:
March 22, 2026
| Id | http://purl.bioontology.org/ontology/MESH/D009459
http://purl.bioontology.org/ontology/MESH/D009459
|
|---|---|
| Preferred Name | Neuroleptic Malignant Syndrome |
| Definitions |
A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
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| Synonyms |
Neuroleptic Induced Neuroleptic Malignant Syndrome
Neuroleptic Malignant Syndrome, Neuroleptic Induced
NMSs (Neuroleptic Malignant Syndrome)
Neuroleptic-Malignant Syndrome, Neuroleptic Induced
Syndromes, Neuroleptic Malignant
NMS (Neuroleptic Malignant Syndrome)
Syndrome, Neuroleptic Malignant
Neuroleptic Malignant Syndromes
Neuroleptic-Induced Neuroleptic Malignant Syndrome
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72) |
|---|---|
| altLabel |
Neuroleptic Induced Neuroleptic Malignant Syndrome
Neuroleptic Malignant Syndrome, Neuroleptic Induced
NMSs (Neuroleptic Malignant Syndrome)
Neuroleptic-Malignant Syndrome, Neuroleptic Induced
Syndromes, Neuroleptic Malignant
NMS (Neuroleptic Malignant Syndrome)
Syndrome, Neuroleptic Malignant
Neuroleptic Malignant Syndromes
Neuroleptic-Induced Neuroleptic Malignant Syndrome
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| prefLabel | Neuroleptic Malignant Syndrome
|
| Machine permutation | 1986; see BASAL GANGLIA DISEASES 1985
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| HN | 1986(1985)
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| type | |
| tui | T047
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| TERMUI |
T364409
T364407
T028186
T364408
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| TH |
NLM (2000)
NLM (1985)
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| MMR | 20100625
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| notation | D009459
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| Semantic type UMLS property | |
| Inverse of AQ |
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| DX | 19860101
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| cui |
C0751376
C0027849
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| DC | 1
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| MN |
C10.228.140.079.737
C10.720.737
C25.723.705.600
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| AN | caused by tranquilizing agents so do not use /chem ind
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| AQL | BL CF CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI
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| MDA | 19990101
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |