Medical Subject Headings

Last uploaded: March 22, 2026
Id http://purl.bioontology.org/ontology/MESH/D006994
http://purl.bioontology.org/ontology/MESH/D006994
Preferred Name

Hypoaldosteronism

Definitions
A congenital or acquired condition of insufficient production of ALDOSTERONE by the ADRENAL CORTEX leading to diminished aldosterone-mediated synthesis of Na(+)-K(+)-EXCHANGING ATPASE in renal tubular cells. Clinical symptoms include HYPERKALEMIA, sodium-wasting, HYPOTENSION, and sometimes metabolic ACIDOSIS. A selective aldosterone deficiency resulting from diminished RENIN-generated ANGIOTENSIN II, a key stimulus to aldosterone secretion. Previously, it was called type IV renal tubular acidosis.
Synonyms
Renal Tubular Acidosis, Type IV
Hypoaldosteronism, Hyporeninemic
Acidosis, Renal Tubular Type IV
Type IV Renal Tubular Acidosis
Hyporeninemic Hypoaldosteronism
Type http://www.w3.org/2002/07/owl#Class
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