Medical Subject Headings

Last uploaded: March 22, 2026
Id http://purl.bioontology.org/ontology/MESH/D006904
http://purl.bioontology.org/ontology/MESH/D006904
Preferred Name

Hydroxymethylglutaryl-CoA Synthase

Definitions
An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. This is a key enzyme in steroid biosynthesis. This enzyme was formerly listed as EC 4.1.3.5.
Synonyms
Synthase, Hydroxymethylglutaryl-CoA
synthase, HMG-CoA
HMG CoA Synthase
Hydroxymethylglutaryl CoA Synthase
3 hydroxy 3 methylglutaryl coenzyme A synthase
A synthase, 3-hydroxy-3-methylglutaryl-coenzyme
CoA Synthase, HMG
synthase, 3-hydroxy-3-methylglutaryl-coenzyme A
3-hydroxy-3-methylglutaryl-coenzyme A synthase
(S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)
Synthase, HMG CoA
HMG-CoA synthase
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Type http://www.w3.org/2002/07/owl#Class
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