Medical Subject Headings

Last uploaded: January 16, 2025
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Id http://purl.bioontology.org/ontology/MESH/D006629
http://purl.bioontology.org/ontology/MESH/D006629
Preferred Name

Hirudins
Definitions
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN. A 65-residue polypeptide from LEECHES.
Synonyms
Hirudin
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.

A 65-residue polypeptide from LEECHES.
altLabel
Hirudin
prefLabel
Hirudins
TH
NLM (1966)
NLM (2005)
notation
D006629
EC
therapeutic use:Hirudin Therapy
RR
8001-27-2
DX
20050101
Machine permutation
2005; see HIRUDIN 1963-2004
MN
D12.644.861.060.875
D12.776.872.060.875
PA
D005343
D000991
MMR
20150622
Mapped from
http://purl.bioontology.org/ontology/MESH/C504439
http://purl.bioontology.org/ontology/MESH/C065961
http://purl.bioontology.org/ontology/MESH/C091596
http://purl.bioontology.org/ontology/MESH/C000615610
http://purl.bioontology.org/ontology/MESH/C479171
http://purl.bioontology.org/ontology/MESH/C064473
http://purl.bioontology.org/ontology/MESH/C100322
http://purl.bioontology.org/ontology/MESH/C470174
http://purl.bioontology.org/ontology/MESH/C000613574
http://purl.bioontology.org/ontology/MESH/C085067
http://purl.bioontology.org/ontology/MESH/C085066
http://purl.bioontology.org/ontology/MESH/C078916
http://purl.bioontology.org/ontology/MESH/C062510
http://purl.bioontology.org/ontology/MESH/C024670
http://purl.bioontology.org/ontology/MESH/C103494
http://purl.bioontology.org/ontology/MESH/C069897
http://purl.bioontology.org/ontology/MESH/C069898
http://purl.bioontology.org/ontology/MESH/C510277
http://purl.bioontology.org/ontology/MESH/C078402
http://purl.bioontology.org/ontology/MESH/C571711
http://purl.bioontology.org/ontology/MESH/C072300
http://purl.bioontology.org/ontology/MESH/C074619
http://purl.bioontology.org/ontology/MESH/C534051
http://purl.bioontology.org/ontology/MESH/C077651
http://purl.bioontology.org/ontology/MESH/C104614
http://purl.bioontology.org/ontology/MESH/C078352
http://purl.bioontology.org/ontology/MESH/C060225
http://purl.bioontology.org/ontology/MESH/C072298
http://purl.bioontology.org/ontology/MESH/C072299
http://purl.bioontology.org/ontology/MESH/C064761
http://purl.bioontology.org/ontology/MESH/C544959
http://purl.bioontology.org/ontology/MESH/C067832
http://purl.bioontology.org/ontology/MESH/C051299
http://purl.bioontology.org/ontology/MESH/C521927
http://purl.bioontology.org/ontology/MESH/C067166
http://purl.bioontology.org/ontology/MESH/C115294
http://purl.bioontology.org/ontology/MESH/C115295
http://purl.bioontology.org/ontology/MESH/C083544
http://purl.bioontology.org/ontology/MESH/C072488
http://purl.bioontology.org/ontology/MESH/C513187
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AQL
AD AE AG AI AN BI BL CF CH CL CS DE EC GE HI IM IP ME PD PH PK PO RE SD ST TO UL UR
HN
2005(1963)
subClassOf
Semantic type UMLS property
Inverse of RB
0
8001-27-2
DC
1
MDA
19990101
Inverse of RO
type
tui
T116
T123
T121
cui
C0019573
C1451270
isa
Inverse of AQ
http://purl.bioontology.org/ontology/MESH/Q000097
http://purl.bioontology.org/ontology/MESH/Q000096
http://purl.bioontology.org/ontology/MESH/Q000648
http://purl.bioontology.org/ontology/MESH/Q000493
http://purl.bioontology.org/ontology/MESH/Q000494
http://purl.bioontology.org/ontology/MESH/Q000276
http://purl.bioontology.org/ontology/MESH/Q000138
http://purl.bioontology.org/ontology/MESH/Q000134
http://purl.bioontology.org/ontology/MESH/Q000266
http://purl.bioontology.org/ontology/MESH/Q000378
http://purl.bioontology.org/ontology/MESH/Q000008
http://purl.bioontology.org/ontology/MESH/Q000009
http://purl.bioontology.org/ontology/MESH/Q000032
http://purl.bioontology.org/ontology/MESH/Q000037
http://purl.bioontology.org/ontology/MESH/Q000191
http://purl.bioontology.org/ontology/MESH/Q000302
http://purl.bioontology.org/ontology/MESH/Q000145
http://purl.bioontology.org/ontology/MESH/Q000592
http://purl.bioontology.org/ontology/MESH/Q000737
http://purl.bioontology.org/ontology/MESH/Q000819
http://purl.bioontology.org/ontology/MESH/Q000502
http://purl.bioontology.org/ontology/MESH/Q000506
http://purl.bioontology.org/ontology/MESH/Q000187
http://purl.bioontology.org/ontology/MESH/Q000235
http://purl.bioontology.org/ontology/MESH/Q000633
http://purl.bioontology.org/ontology/MESH/Q000600
http://purl.bioontology.org/ontology/MESH/Q000652
http://purl.bioontology.org/ontology/MESH/Q000528
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TERMUI
T019948
T586622
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