loading...| Preferred Name |
Glucose-6-Phosphate Isomerase |
|
| Synonyms |
Tumor-Cell Autocrine Motility Factor Glucosephosphate Isomerase Neuroleukin Phosphoglucose Isomerase Motility Factor, Autocrine Isomerase, Glucose 6 Phosphate Phosphohexose Isomerase Autocrine Motility Factor D-Glucose-6-phosphate ketol-isomerase Tumor Cell Autocrine Motility Factor Tumor Autocrine Motility Factor Isomerase, Phosphoglucose Factor, Autocrine Motility Isomerase, Glucosephosphate Glucose 6 Phosphate Isomerase Isomerase, Glucose-6-Phosphate Isomerase, Phosphohexose |
|
| Definitions |
An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA. A secreted form of glucose-6-phosphate isomerase. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D005956 |
|
| altLabel |
Tumor-Cell Autocrine Motility Factor Glucosephosphate Isomerase Neuroleukin Phosphoglucose Isomerase Motility Factor, Autocrine Isomerase, Glucose 6 Phosphate Phosphohexose Isomerase Autocrine Motility Factor D-Glucose-6-phosphate ketol-isomerase Tumor Cell Autocrine Motility Factor Tumor Autocrine Motility Factor Isomerase, Phosphoglucose Factor, Autocrine Motility Isomerase, Glucosephosphate Glucose 6 Phosphate Isomerase Isomerase, Glucose-6-Phosphate Isomerase, Phosphohexose |
|
| AQL |
AD AE AI AN BI BL CF CH CL CS DE EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR |
|
| cui |
C0085144 C0017759 |
|
| DC |
1 |
|
| definition |
An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA. A secreted form of glucose-6-phosphate isomerase. |
|
| DX |
19650101 |
|
| EC |
deficiency:Anemia, Hemolytic, Congenital Nonspherocytic |
|
| HN |
1998(1965) |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
| Inverse of RB |
EC 5.3.1.9 |
|
| Machine permutation |
1998; see GLUCOSEPHOSPHATE ISOMERASE 1965-1997; for AUTOCRINE MOTILITY FACTOR see AUTOCRINE MOTILITY FACTOR 1992-2011; for NEUROLEUKIN see NEUROLEUKIN 1990-2011 |
|
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C554960 http://purl.bioontology.org/ontology/MESH/C554962 http://purl.bioontology.org/ontology/MESH/C554958 |
|
| MDA |
19990101 |
|
| MMR |
20190701 |
|
| MN |
D08.811.399.475.200.350 |
|
| notation |
D005956 |
|
| prefLabel |
Glucose-6-Phosphate Isomerase |
|
| RR |
EC 5.3.1.9 |
|
| TERMUI |
T049527 T018045 T049526 T018043 T018046 T018047 T018044 T049525 T046804 |
|
| TH |
NLM (1965) NLM (1990) NLM (1992) UNK (19XX) NLM (1998) |
|
| tui |
T116 T129 T126 |
|
| subClassOf |