loading...| Preferred Name |
Gene Amplification |
|
| Synonyms |
Amplification, Gene |
|
| Definitions |
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D005784 |
|
| altLabel |
Amplification, Gene |
|
| AN |
for physiol process only; for technique use NUCLEIC ACID AMPLIFICATION TECHNIQUES or specifics |
|
| AQL |
DE ES GE IM PH RE |
|
| cui |
C0017256 |
|
| DC |
1 |
|
| definition |
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication. |
|
| DX |
19800101 |
|
| EC |
methods:Nucleic Acid Amplification Techniques |
|
| FX |
D018628 |
|
| HN |
80 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000941 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000187 |
|
| Inverse of RO | ||
| Machine permutation |
80 |
|
| MDA |
19790417 |
|
| MMR |
20160617 |
|
| MN |
G05.308.250 G05.558.315 G05.365.590.310 |
|
| notation |
D005784 |
|
| prefLabel |
Gene Amplification |
|
| TERMUI |
T017427 |
|
| TH |
NLM (1980) |
|
| tui |
T045 |
|
| subClassOf |
http://purl.bioontology.org/ontology/MESH/D005786 |