Medical Subject Headings

Last uploaded: January 16, 2025
Id http://purl.bioontology.org/ontology/MESH/D005047
http://purl.bioontology.org/ontology/MESH/D005047
Preferred Name

Etoposide

Definitions
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Synonyms
Etoposide Pierre Fabre
Riboposid
Teva, Etoposide
Eto-GRY
Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 9-((4,6-O-ethylidene-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-
Etopos
Eto GRY
Exitop
Vepesid
NSC 141540
VP 16213
Etoposido Ferrer Farma
Lastet
Etoposide Teva
VP-16
Onkoposid
VP 16 213
Vépéside Sandoz
Eposide
Etomedac
VP 16-213
Etoposide, alpha D Glucopyranosyl Isomer
Etoposide, (5S)-Isomer
Celltop
Etoposide, (5a alpha)-Isomer
Toposar
Vépéside-Sandoz
Etoposide, alpha-D-Glucopyranosyl Isomer
NSC141540
NSC-141540
Etoposide, (5a alpha,9 alpha)-Isomer
Eposin
Demethyl Epipodophyllotoxin Ethylidine Glucoside
alpha-D-Glucopyranosyl Isomer Etoposide
VP16
VP 16
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Type http://www.w3.org/2002/07/owl#Class
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