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January 16, 2025
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Id | http://purl.bioontology.org/ontology/MESH/D005047
http://purl.bioontology.org/ontology/MESH/D005047
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Preferred Name | Etoposide |
Definitions |
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
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Synonyms |
Etoposide Pierre Fabre
Riboposid
Teva, Etoposide
Eto-GRY
Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 9-((4,6-O-ethylidene-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-
Etopos
Eto GRY
Exitop
Vepesid
NSC 141540
VP 16213
Etoposido Ferrer Farma
Lastet
Etoposide Teva
VP-16
Onkoposid
VP 16 213
Vépéside Sandoz
Eposide
Etomedac
VP 16-213
Etoposide, alpha D Glucopyranosyl Isomer
Etoposide, (5S)-Isomer
Celltop
Etoposide, (5a alpha)-Isomer
Toposar
Vépéside-Sandoz
Etoposide, alpha-D-Glucopyranosyl Isomer
NSC141540
NSC-141540
Etoposide, (5a alpha,9 alpha)-Isomer
Eposin
Demethyl Epipodophyllotoxin Ethylidine Glucoside
alpha-D-Glucopyranosyl Isomer Etoposide
VP16
VP 16
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
definition | A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. |
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altLabel |
Etoposide Pierre Fabre
Riboposid
Teva, Etoposide
Eto-GRY
Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 9-((4,6-O-ethylidene-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-
Etopos
Eto GRY
Exitop
Vepesid
NSC 141540
VP 16213
Etoposido Ferrer Farma
Lastet
Etoposide Teva
VP-16
Onkoposid
VP 16 213
Vépéside Sandoz
Eposide
Etomedac
VP 16-213
Etoposide, alpha D Glucopyranosyl Isomer
Etoposide, (5S)-Isomer
Celltop
Etoposide, (5a alpha)-Isomer
Toposar
Vépéside-Sandoz
Etoposide, alpha-D-Glucopyranosyl Isomer
NSC141540
NSC-141540
Etoposide, (5a alpha,9 alpha)-Isomer
Eposin
Demethyl Epipodophyllotoxin Ethylidine Glucoside
alpha-D-Glucopyranosyl Isomer Etoposide
VP16
VP 16
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prefLabel |
Etoposide
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TH |
NLM (1996)
US
MX
UK
NL
NLM (1999)
CA
FDA SRS (2014)
ES
UNK (19XX)
USAN (1978)
INN (19XX)
DE
AU
USP (19XX)
BAN (19XX)
FR
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notation |
D005047
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RR |
96554-41-5 ((5a alpha,9 alpha)-isomer)
33419-42-0 (Etoposide)
100007-53-2 (alpha-D-glucopyranosyl isomer)
89301-95-1 ((5S)-isomer)
96554-38-0 ((5a alpha)-isomer)
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DX |
19870101
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Machine permutation |
87; was see under PODOPHYLLOTOXIN 1981-86; was VP 16-213 see under PODOPHYLLOTOXIN 1976-80
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MN |
D02.455.426.559.847.638.960.675.250
D09.408.348.275
D04.615.638.960.675.250
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PA |
D059005
D000972
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MMR |
20180301
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Mapped from |
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AQL |
AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
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HN |
87(81); was see under PODOPHYLLOTOXIN 1981-86; was VP 16-213 see under PODOPHYLLOTOXIN 1976-80
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subClassOf | |
Semantic type UMLS property | |
Inverse of RB |
96554-41-5
100007-53-2
96554-38-0
89301-95-1
6PLQ3CP4P3
0
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LT |
TRD
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DC |
1
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MDA |
19750725
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type | |
tui |
T109
T121
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cui |
C0733689
C0887321
C1564690
C0887319
C1564691
C0700191
C0887318
C1564687
C1564684
C0723782
C1564689
C1516981
C1564693
C0733688
C1564686
C0015133
C4704879
C1564685
C0733687
C1564694
C0887320
C1564692
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isa | |
Inverse of AQ |
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OL |
use ETOPOSIDE to search VP 16-213 1976-80
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TERMUI |
T015432
T624931
T360568
T360570
T624942
T624927
T015433
T624940
T015434
T015435
T624925
T624918
T624935
T624937
T015431
T360569
T624915
T624922
T015429
T624917
T624929
T015430
T624933
T624944
T360567
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