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Last uploaded: January 31, 2024

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Preferred Name	Leucovorin
Synonyms	Leucovorin, Calcium Leucovorin, Calcium (1:1) Salt, (DL)-Isomer
Definitions	The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.
ID	http://purl.bioontology.org/ontology/MESH/D002955
altLabel	Leucovorin, Calcium 5-Formyltetrahydropteroylglutamate 5 Formyltetrahydrofolate Folinic Acid SF Acid, Folinic 5-Formyltetrahydrofolate Wellcovorin Leucovorin, Calcium (1:1) Salt 5 Formyltetrahydropteroylglutamate Calcium Leucovorin Factor, Citrovorum N(5)-Formyltetrahydrofolate Citrovorum Factor Calcium Folinate Leucovorin, (DL)-Isomer Monosodium Salt Leucovorin L-Glutamic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)- Leucovorin, Monosodium Salt Leukovorum Leucovorin, Calcium (1:1) Salt, Pentahydrate Leukovorin Folinate, Calcium Folinic Acid-SF Folinic Acid Leucovorin, (R)-Isomer Leucovorin, (D)-Isomer Leucovorin, Calcium (1:1) Salt, (DL)-Isomer
AN	deficiency: coordinate LEUCOVORIN /defic (IM) with FOLIC ACID DEFICIENCY (IM)
AQL	AA AD AE AG AI AN BI BL CF CH CL CS DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UR
cui	C0971861 C0887508 C4048232 C0887502 C0731033 C0023413 C0949262 C0701377 C0887504 C0949260 C0949263
DC	1
definition	The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.
DX	19900101
HN	90; was CITROVORUM FACTOR 1964-89
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	RPR1R4C0P4 1492-18-8 42476-21-1 Q573I9DVLP 54353-24-1 6035-45-6 73951-54-9 22350-60-3 0 67005-79-2
isa	http://purl.bioontology.org/ontology/MESH/D014803 http://purl.bioontology.org/ontology/MESH/D000931
LT	TRD
Machine permutation	90; was CITROVORUM FACTOR 1964-89
Mapped from	http://purl.bioontology.org/ontology/MESH/C417165 http://purl.bioontology.org/ontology/MESH/C044683 http://purl.bioontology.org/ontology/MESH/C081087 http://purl.bioontology.org/ontology/MESH/C491688 http://purl.bioontology.org/ontology/MESH/C070074 http://purl.bioontology.org/ontology/MESH/C080085 http://purl.bioontology.org/ontology/MESH/C402730 http://purl.bioontology.org/ontology/MESH/C066366 http://purl.bioontology.org/ontology/MESH/C034857 http://purl.bioontology.org/ontology/MESH/C092462 http://purl.bioontology.org/ontology/MESH/C092461 http://purl.bioontology.org/ontology/MESH/C087494 http://purl.bioontology.org/ontology/MESH/C079346 http://purl.bioontology.org/ontology/MESH/C067757 http://purl.bioontology.org/ontology/MESH/C043207 http://purl.bioontology.org/ontology/MESH/C053038 http://purl.bioontology.org/ontology/MESH/C053039 http://purl.bioontology.org/ontology/MESH/C044144 http://purl.bioontology.org/ontology/MESH/C099767 http://purl.bioontology.org/ontology/MESH/C085788 http://purl.bioontology.org/ontology/MESH/C503998 http://purl.bioontology.org/ontology/MESH/C060950 http://purl.bioontology.org/ontology/MESH/C085328 http://purl.bioontology.org/ontology/MESH/C110432 http://purl.bioontology.org/ontology/MESH/C438309 http://purl.bioontology.org/ontology/MESH/C038173 http://purl.bioontology.org/ontology/MESH/C071785 http://purl.bioontology.org/ontology/MESH/C045974 http://purl.bioontology.org/ontology/MESH/C059510 http://purl.bioontology.org/ontology/MESH/C047851 http://purl.bioontology.org/ontology/MESH/C103740 http://purl.bioontology.org/ontology/MESH/C111758 http://purl.bioontology.org/ontology/MESH/C429268 http://purl.bioontology.org/ontology/MESH/C035353 http://purl.bioontology.org/ontology/MESH/C060656 http://purl.bioontology.org/ontology/MESH/C007776 http://purl.bioontology.org/ontology/MESH/C408045 http://purl.bioontology.org/ontology/MESH/C107305 http://purl.bioontology.org/ontology/MESH/C035380 http://purl.bioontology.org/ontology/MESH/C090904 http://purl.bioontology.org/ontology/MESH/C051761 http://purl.bioontology.org/ontology/MESH/C057600 http://purl.bioontology.org/ontology/MESH/C114848 http://purl.bioontology.org/ontology/MESH/C072254 http://purl.bioontology.org/ontology/MESH/C072253 http://purl.bioontology.org/ontology/MESH/C400981 http://purl.bioontology.org/ontology/MESH/C087705 http://purl.bioontology.org/ontology/MESH/C415255 http://purl.bioontology.org/ontology/MESH/C044922 http://purl.bioontology.org/ontology/MESH/C010161 http://purl.bioontology.org/ontology/MESH/C401502 http://purl.bioontology.org/ontology/MESH/C401501 http://purl.bioontology.org/ontology/MESH/C401503 http://purl.bioontology.org/ontology/MESH/C073795 http://purl.bioontology.org/ontology/MESH/C410217 http://purl.bioontology.org/ontology/MESH/C410216 http://purl.bioontology.org/ontology/MESH/C043997 http://purl.bioontology.org/ontology/MESH/C069961 http://purl.bioontology.org/ontology/MESH/C034798 http://purl.bioontology.org/ontology/MESH/C062400 http://purl.bioontology.org/ontology/MESH/C058153 http://purl.bioontology.org/ontology/MESH/C089162 http://purl.bioontology.org/ontology/MESH/C482642 http://purl.bioontology.org/ontology/MESH/C072710 http://purl.bioontology.org/ontology/MESH/C507844 http://purl.bioontology.org/ontology/MESH/C096219 http://purl.bioontology.org/ontology/MESH/C402728 http://purl.bioontology.org/ontology/MESH/C480833 http://purl.bioontology.org/ontology/MESH/C452319 http://purl.bioontology.org/ontology/MESH/C042593 http://purl.bioontology.org/ontology/MESH/C078351 http://purl.bioontology.org/ontology/MESH/C075196 http://purl.bioontology.org/ontology/MESH/C099563 http://purl.bioontology.org/ontology/MESH/C049341 http://purl.bioontology.org/ontology/MESH/C092090 http://purl.bioontology.org/ontology/MESH/C040271 http://purl.bioontology.org/ontology/MESH/C038359 http://purl.bioontology.org/ontology/MESH/C403590 http://purl.bioontology.org/ontology/MESH/C502887 http://purl.bioontology.org/ontology/MESH/C045260 http://purl.bioontology.org/ontology/MESH/C119345 http://purl.bioontology.org/ontology/MESH/C109456 http://purl.bioontology.org/ontology/MESH/C035879 http://purl.bioontology.org/ontology/MESH/C000627770 http://purl.bioontology.org/ontology/MESH/C509829 http://purl.bioontology.org/ontology/MESH/C112769 http://purl.bioontology.org/ontology/MESH/C045045
MDA	19990101
MMR	20160531
MN	D03.633.100.733.631.400.800.350.450 D08.211.840.300.500
notation	D002955
OL	use LEUCOVORIN to search CITROVORUM FACTOR 1966-89
PA	D000931 D014803
prefLabel	Leucovorin
RR	RPR1R4C0P4 58-05-9 (Leucovorin) 1492-18-8 42476-21-1 54353-24-1 6035-45-6 73951-54-9 22350-60-3 67005-79-2
TERMUI	T008556 T008547 T008550 T360862 T360863 T008553 T360868 T360861 T008555 T008548 T008557 T360864 T008558 T008552 T008554 T008546 T008549 T360865 T360866
TH	NLM (1999) NLM (1966) NLM (1990) FDA SRS (2014) UNK (19XX) USAN (19XX) INN (19XX) NLM (1998) FDA SRS (2015)
tui	T109 T127 T121
subClassOf	http://purl.bioontology.org/ontology/MESH/D005575

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/NDFRT/N0000184018	NDFRT	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/396065004	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/VANDF/4018768	VANDF	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000042584	PDQ	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000179674	NDFRT	CUI
http://purl.bioontology.org/ontology/SNMI/F-BB410	SNMI	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/126223008	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/RXNORM/225852	RXNORM	CUI
http://purl.bioontology.org/ontology/ATC/V03AF03	ATC	CUI
http://purl.bioontology.org/ontology/SNMI/C-A4412	SNMI	CUI
http://purl.bioontology.org/ontology/VANDF/4031236	VANDF	CUI
http://purl.bioontology.org/ontology/RCD/x040h	RCD	CUI
http://purl.bioontology.org/ontology/SCTSPA/126223008	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147071	NDFRT	CUI
http://purl.bioontology.org/ontology/NDDF/001051	NDDF	CUI
http://purl.bioontology.org/ontology/RCD/i34..	RCD	CUI
http://purl.bioontology.org/ontology/CSP/3147-1098	CRISP	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/1528001	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000042584	PDQ	CUI
http://purl.bioontology.org/ontology/SNMI/F-BB410	SNMI	CUI
http://purl.bioontology.org/ontology/SCTSPA/1528001	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147887	NDFRT	CUI
http://purl.bioontology.org/ontology/SNMI/C-A4414	SNMI	CUI
http://purl.bioontology.org/ontology/SNMI/C-A4412	SNMI	CUI
http://purl.bioontology.org/ontology/SNMI/C-A4413	SNMI	CUI
http://purl.bioontology.org/ontology/NDDF/001050	NDDF	CUI
http://purl.bioontology.org/ontology/SNMI/F-BB420	SNMI	CUI
http://purl.bioontology.org/ontology/MSHFRE/D002955	MSHFRE	CUI
http://purl.bioontology.org/ontology/LNC/LA14337-2	LOINC	CUI
http://purl.bioontology.org/ontology/RXNORM/6313	RXNORM	CUI
http://purl.bioontology.org/ontology/SCTSPA/396065004	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000007083	NDFRT	CUI
http://purl.bioontology.org/ontology/VANDF/4019798	VANDF	CUI
http://purl.bioontology.org/ontology/RCD/i34..	RCD	CUI
http://purl.obolibrary.org/obo/dinto_DB00650	DINTO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/396065004	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/CSP/3147-1098	CRISP	LOOM
http://purl.jp/bio/4/id/200906019893037763	IOBC	LOOM
http://purl.obolibrary.org/obo/OMIT_0004271	OMIT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#7328	OCHV	LOOM
https://go.drugbank.com/drugs/DB00650	MDM	LOOM
http://purl.obolibrary.org/obo/MESH_D002955	BERO	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71631	NCIT	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017779	PMAPP-PMO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.733.631.400.800.350.450	RH-MESH	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147887	NDFRT	LOOM
http://doe-generated-ontology.com/OntoAD#C0023413	ONTOAD	LOOM
http://purl.bioontology.org/ontology/NDDF/001050	NDDF	LOOM
http://www.drugbank.ca/drugs/DB00650	FTC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0023413	OCHV	LOOM
http://purl.obolibrary.org/obo/NCIT_C71631	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002955	RH-MESH	LOOM
http://purl.bioontology.org/ontology/LNC/LA14337-2	LOINC	LOOM
http://purl.bioontology.org/ontology/RXNORM/6313	NLMVS	LOOM
http://purl.bioontology.org/ontology/RXNORM/6313	RXNORM	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.211.840.300.500	RH-MESH	LOOM
http://purl.bioontology.org/ontology/NLMVS/2.16.840.1.113883.3.464.1003.196.12.1205	NLMVS	LOOM
http://stirdf.jst.go.jp/id/200907028453704434	IOBC	LOOM
http://purl.bioontology.org/ontology/VANDF/4019798	VANDF	LOOM