Medical Subject Headings

Last uploaded: January 31, 2024

Details
Visualization
Notes ( 0 )
Class Mappings ( )

Preferred Name	Histocompatibility Antigens Class II
Synonyms	Ia Antigens Antigens, Immune Response Immune Associated Antigens Antigen, IA Immune-Associated Antigens Immune-Response-Associated Antigens MHC-II Molecules MHC II Molecules Peptide, MHC II I-A Antigen MHC Class II Molecule Ia-Like Antigen Immune Response Antigens Antigen, I-A Antigens, Class II Class II Histocompatibility Antigens Ia-Like Antigens Antigen, Class II MHC II Peptides Immune Response Associated Antigens Antigens, Ia Antigen, Ia-Like Antigens, Ia-Like MHC Class II Molecules Class II Major Histocompatibility Molecules Class II MHC Proteins I A Antigen II Peptide, MHC Ia Like Antigens Class II Major Histocompatibility Antigen Class II Major Histocompatibility Antigens MHC II Peptide Ia Like Antigen I-A-Antigen Molecules, MHC-II Peptides, MHC II Antigens, Immune-Associated Class II Antigens IA Antigen Class II Antigen Class II Histocompatibility Antigen Antigens, Immune-Response-Associated
Definitions	Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
ID	http://purl.bioontology.org/ontology/MESH/D000949
altLabel	Ia Antigens Antigens, Immune Response Immune Associated Antigens Antigen, IA Immune-Associated Antigens Immune-Response-Associated Antigens MHC-II Molecules MHC II Molecules Peptide, MHC II I-A Antigen MHC Class II Molecule Ia-Like Antigen Immune Response Antigens Antigen, I-A Antigens, Class II Class II Histocompatibility Antigens Ia-Like Antigens Antigen, Class II MHC II Peptides Immune Response Associated Antigens Antigens, Ia Antigen, Ia-Like Antigens, Ia-Like MHC Class II Molecules Class II Major Histocompatibility Molecules Class II MHC Proteins I A Antigen II Peptide, MHC Ia Like Antigens Class II Major Histocompatibility Antigen Class II Major Histocompatibility Antigens MHC II Peptide Ia Like Antigen I-A-Antigen Molecules, MHC-II Peptides, MHC II Antigens, Immune-Associated Class II Antigens IA Antigen Class II Antigen Class II Histocompatibility Antigen Antigens, Immune-Response-Associated
AN	human & animal; see also HLA ANTIGENS & specifics for human
AQL	AD AN BI BL CF CH CL DE EC GE HI IM IP ME PD PH PO RE TO TU UL UR
cui	C0019630 C0086452
DC	1
definition	Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
DX	19810101
FX	D005802
HN	1989 (1973); use ANTIGENS, IMMUNE RESPONSE 1981-88
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	0
Inverse of RO	http://purl.bioontology.org/ontology/MESH/D015847 http://purl.bioontology.org/ontology/MESH/D005802 http://purl.bioontology.org/ontology/MESH/D000938
Machine permutation	1989; see ANTIGENS, IMMUNE RESPONSE 1981-88
Mapped from	http://purl.bioontology.org/ontology/MESH/C098078 http://purl.bioontology.org/ontology/MESH/C000706448 http://purl.bioontology.org/ontology/MESH/C489629 http://purl.bioontology.org/ontology/MESH/C489628 http://purl.bioontology.org/ontology/MESH/C043911 http://purl.bioontology.org/ontology/MESH/C423282 http://purl.bioontology.org/ontology/MESH/C045084 http://purl.bioontology.org/ontology/MESH/C088543 http://purl.bioontology.org/ontology/MESH/C088544 http://purl.bioontology.org/ontology/MESH/C574733 http://purl.bioontology.org/ontology/MESH/C062893 http://purl.bioontology.org/ontology/MESH/C098096 http://purl.bioontology.org/ontology/MESH/C094595 http://purl.bioontology.org/ontology/MESH/C094597 http://purl.bioontology.org/ontology/MESH/C474482 http://purl.bioontology.org/ontology/MESH/C024138 http://purl.bioontology.org/ontology/MESH/C092258 http://purl.bioontology.org/ontology/MESH/C041136 http://purl.bioontology.org/ontology/MESH/C111388 http://purl.bioontology.org/ontology/MESH/C111389 http://purl.bioontology.org/ontology/MESH/C507068 http://purl.bioontology.org/ontology/MESH/C445501 http://purl.bioontology.org/ontology/MESH/C042225 http://purl.bioontology.org/ontology/MESH/C094588 http://purl.bioontology.org/ontology/MESH/C407099 http://purl.bioontology.org/ontology/MESH/C049515 http://purl.bioontology.org/ontology/MESH/C416189 http://purl.bioontology.org/ontology/MESH/C416186
MDA	19800513
MMR	20230316
MN	D23.050.705.552.410 D23.050.301.500.400 D12.776.543.550.440 D12.776.395.550.509 D09.400.430.890.509
notation	D000949
prefLabel	Histocompatibility Antigens Class II
TERMUI	T002861 T002854 T001089287 T002855 T002862 T002853 T002851 T001089290 T000936559 T000936563 T000936560 T001089286 T000936562 T002860 T002849 T002859 T002856 T002850 T000936561 T001089289 T002852 T002858 T001089292 T002857
TH	NLM (2019) NLM (1994) NLM (1992) UNK (19XX) NLM (2022) NLM (1981)
tui	T116 T129
subClassOf	http://purl.bioontology.org/ontology/MESH/D008562 http://purl.bioontology.org/ontology/MESH/D006649

Add comment

Add proposal

Subscribe to notes emails

Delete	Subject	Author	Type	Created
No notes to display

Create mapping

Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/CSP/2935-6335	CRISP	CUI
http://purl.bioontology.org/ontology/MSHFRE/D000949	MSHFRE	CUI
http://purl.bioontology.org/ontology/MSHFRE/D000949	MSHFRE	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000171090	NDFRT	CUI
http://doe-generated-ontology.com/OntoAD#C0019630	ONTOAD	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D23.050.301.500.400	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.543.550.423	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D23.050.705.552.410	RH-MESH	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00022880	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/OMIT_0002345	OMIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D000949	RH-MESH	LOOM
http://purl.obolibrary.org/obo/MESH_D000949	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.395.550.509	RH-MESH	LOOM