Medical Subject Headings

Last uploaded: March 22, 2026

Id	http://purl.bioontology.org/ontology/MESH/D000584 http://purl.bioontology.org/ontology/MESH/D000584
Preferred Name	Amiloride
Definitions	A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Synonyms	Amidal Trom, Amiduret Hydrochloride, Amiloride Midamor Amiloride Hydrochloride Amiduret Trom Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro- Anhydrous Amiloride Hydrochloride Midoride Hydrochloride, Anhydrous Amiloride Kaluril Amiloberag Modamide Amiloride Hydrochloride, Anhydrous See more See less
Type	http://www.w3.org/2002/07/owl#Class

definition	A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
altLabel	Amidal Trom, Amiduret Hydrochloride, Amiloride Midamor Amiloride Hydrochloride Amiduret Trom Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro- Anhydrous Amiloride Hydrochloride Midoride Hydrochloride, Anhydrous Amiloride Kaluril Amiloberag Modamide Amiloride Hydrochloride, Anhydrous See more See less
prefLabel	Amiloride
Machine permutation	86; was see under PYRAZINES 1975-85
HN	86(72); was see under PYRAZINES 1975-85, was Prov 1972-74
Mapped from	http://purl.bioontology.org/ontology/MESH/C047088 http://purl.bioontology.org/ontology/MESH/C029229 http://purl.bioontology.org/ontology/MESH/C048793 http://purl.bioontology.org/ontology/MESH/C064150 http://purl.bioontology.org/ontology/MESH/C043988 http://purl.bioontology.org/ontology/MESH/C421266 http://purl.bioontology.org/ontology/MESH/C047657 http://purl.bioontology.org/ontology/MESH/C010247 http://purl.bioontology.org/ontology/MESH/C056107 http://purl.bioontology.org/ontology/MESH/C039465 http://purl.bioontology.org/ontology/MESH/C051584 http://purl.bioontology.org/ontology/MESH/C066056 http://purl.bioontology.org/ontology/MESH/C063513 http://purl.bioontology.org/ontology/MESH/C063512 http://purl.bioontology.org/ontology/MESH/C064515 http://purl.bioontology.org/ontology/MESH/C053837 http://purl.bioontology.org/ontology/MESH/C058206 http://purl.bioontology.org/ontology/MESH/C076306 http://purl.bioontology.org/ontology/MESH/C076305 http://purl.bioontology.org/ontology/MESH/C000592315 http://purl.bioontology.org/ontology/MESH/C000604937 http://purl.bioontology.org/ontology/MESH/C057360 http://purl.bioontology.org/ontology/MESH/C044677 http://purl.bioontology.org/ontology/MESH/C029230 http://purl.bioontology.org/ontology/MESH/C050820 http://purl.bioontology.org/ontology/MESH/C040679 http://purl.bioontology.org/ontology/MESH/C061007 http://purl.bioontology.org/ontology/MESH/C054391 http://purl.bioontology.org/ontology/MESH/C034428 http://purl.bioontology.org/ontology/MESH/C584412 http://purl.bioontology.org/ontology/MESH/C046878 http://purl.bioontology.org/ontology/MESH/C067984 http://purl.bioontology.org/ontology/MESH/C058269 http://purl.bioontology.org/ontology/MESH/C039614 http://purl.bioontology.org/ontology/MESH/C055284 http://purl.bioontology.org/ontology/MESH/C046793 http://purl.bioontology.org/ontology/MESH/C081564 http://purl.bioontology.org/ontology/MESH/C084633 http://purl.bioontology.org/ontology/MESH/C013407 http://purl.bioontology.org/ontology/MESH/C066916 http://purl.bioontology.org/ontology/MESH/C053494 http://purl.bioontology.org/ontology/MESH/C056369 http://purl.bioontology.org/ontology/MESH/C050819 http://purl.bioontology.org/ontology/MESH/C041470 http://purl.bioontology.org/ontology/MESH/C070708 http://purl.bioontology.org/ontology/MESH/C051690 http://purl.bioontology.org/ontology/MESH/C076676 http://purl.bioontology.org/ontology/MESH/C049046 See more See less
type	http://www.w3.org/2002/07/owl#Class
isa	http://purl.bioontology.org/ontology/MESH/D004232 http://purl.bioontology.org/ontology/MESH/D062686 http://purl.bioontology.org/ontology/MESH/D062646
PA	D062646 D062686 D004232
tui	T109 T121
TERMUI	T001776 T506667 T001777 T360951 T001775 T506665 T506671 T506664 T506673 T506669 See more See less
TH	US UK NL NLM (1999) CA USAN (1967) FDA SRS (2014) INN (19XX) DE AU USP (19XX) BAN (19XX) FR IE See more See less
MMR	20170524
notation	D000584
Semantic type UMLS property	http://purl.bioontology.org/ontology/STY/T121 http://purl.bioontology.org/ontology/STY/T109
RR	2609-46-3 (Amiloride) 17440-83-4 (Amiloride Hydrochloride) FZJ37245UC 2016-88-8
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528 See more See less
DX	19860101
cui	C1448394 C1448395 C0718462 C0949217 C0026054 C1448396 C1448397 C0002502 C0546849 See more See less
DC	1
MN	D03.383.679.149
LT	TRD
AQL	AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
Inverse of RB	FZJ37245UC 7DZO8EB0Z3 0 2016-88-8
MDA	19990101
subClassOf	http://purl.bioontology.org/ontology/MESH/D011719

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