loading...| Preferred Name | Polyether Polyketides | |
| Synonyms |
Polyether Antibiotics Polyether Ionophore Antibiotics Marine Ladder Polyethers Polyether Ionophores |
|
| Definitions |
Polycyclic polyketides with distinctive ladder shaped multiple polyether motifs. In STREPTOMYCES polycyclic polyketide backbones are assembled by type I modular polyketide synthases which then are modified by epoxidase and epoxide hydrolase to achieve their stereochemistry. Polyether ionophore antibiotics coordinate alkali metal cations with their multiple oxygen atoms which disturbs sodium/potassium concentration gradient. They are widely used to treat and control COCCIDIOSIS. Structurally related MARINE LADDER POLYETHERS are neurotoxins. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D000095662 |
|
| altLabel |
Polyether Antibiotics Polyether Ionophore Antibiotics Marine Ladder Polyethers Polyether Ionophores |
|
| AQL |
AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR |
|
| cui |
C5828283 C5828284 C5828282 |
|
| DC |
1 |
|
| definition |
Polycyclic polyketides with distinctive ladder shaped multiple polyether motifs. In STREPTOMYCES polycyclic polyketide backbones are assembled by type I modular polyketide synthases which then are modified by epoxidase and epoxide hydrolase to achieve their stereochemistry. Polyether ionophore antibiotics coordinate alkali metal cations with their multiple oxygen atoms which disturbs sodium/potassium concentration gradient. They are widely used to treat and control COCCIDIOSIS. Structurally related MARINE LADDER POLYETHERS are neurotoxins. |
|
| DX |
20240101 |
|
| HN |
2024 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
| Inverse of RB |
0 |
|
| Machine permutation |
2024 |
|
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C572421 http://purl.bioontology.org/ontology/MESH/C490954 http://purl.bioontology.org/ontology/MESH/C015117 http://purl.bioontology.org/ontology/MESH/C000597650 http://purl.bioontology.org/ontology/MESH/C013374 http://purl.bioontology.org/ontology/MESH/C070519 http://purl.bioontology.org/ontology/MESH/C010327 |
|
| MDA |
20230726 |
|
| MMR |
20230226 |
|
| MN |
D04.345.241.654 D04.345.674.625 D02.540.576.625 D02.355.291.933 |
|
| notation |
D000095662 |
|
| prefLabel |
Polyether Polyketides |
|
| TERMUI |
T001124908 T001124909 T001124911 T001125008 T001124907 |
|
| TH |
NLM (2024) |
|
| tui |
T109 T195 T123 |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.bioontology.org/ontology/MSHFRE/D000095662 | MSHFRE | CUI | |
| http://purl.bioontology.org/ontology/MSHFRE/D000095662 | MSHFRE | CUI | |
| http://purl.bioontology.org/ontology/MSHFRE/D000095662 | MSHFRE | CUI |