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Medical Subject Headings
Last uploaded:
March 22, 2026
| Id | http://purl.bioontology.org/ontology/MESH/D000077339
http://purl.bioontology.org/ontology/MESH/D000077339
|
|---|---|
| Preferred Name | Leflunomide |
| Definitions |
An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
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| Synonyms |
HWA-486
SU101
N-(4-Trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide
Arava
4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)-
HWA486
HWA 486
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS. |
|---|---|
| altLabel |
HWA-486
SU101
N-(4-Trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide
Arava
4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)-
HWA486
HWA 486
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|
| prefLabel | Leflunomide
|
| Machine permutation | 2019; LEFLUNOMIDE was indexed under ISOXAZOLES 1991-2018; and under OXAZOLES 1985-1990
|
| HN | 2019 (1985)
|
| type | |
| isa | |
| PA |
D004791
D007166
|
| tui |
T109
T121
|
| TERMUI |
T000939396
T000939397
T429403
T162175
T461991
T162174
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| TH |
US
USAN (1990)
UK
NLM (2000)
NL
CA
ES
NLM (1985)
INN (19XX)
DE
AU
FDA SRS (2015)
FR
IE
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| MMR | 20190101
|
| notation | D000077339
|
| Semantic type UMLS property | |
| RR | 75706-12-6 (Leflunomide)
|
| Inverse of AQ |
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| DX | 20190101
|
| cui |
C0063041
C0966994
C0718644
C0122694
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| DC | 1
|
| MN | D03.383.129.385.475
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| LT | TRD
|
| AQL | AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
|
| Inverse of RB |
G162GK9U4W
0
|
| MDA | 20180119
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| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |