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Medical Subject Headings
Last uploaded:
March 22, 2026
| Id | http://purl.bioontology.org/ontology/MESH/D000077297
http://purl.bioontology.org/ontology/MESH/D000077297
|
|---|---|
| Preferred Name | Pregnane X Receptor |
| Definitions |
Steroid receptor that binds and is activated by variety of endogenous compounds and XENOBIOTICS. It binds the response element in promoters of genes that encode CYTOCHROME P450 3A4 and ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 proteins, and also activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs, and endogenous compounds. It is activated by the antibiotic RIFAMPICIN and various plant metabolites, such as hyperforin, guggulipid, colupulone, and ISOFLAVONES.
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| Synonyms |
Steroid X Receptor
SXR Receptor
Nuclear Receptor Subfamily 1, Group I, Member 2
NR1I2
Steroid and Xenobiotic Receptor
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Steroid receptor that binds and is activated by variety of endogenous compounds and XENOBIOTICS. It binds the response element in promoters of genes that encode CYTOCHROME P450 3A4 and ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 proteins, and also activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs, and endogenous compounds. It is activated by the antibiotic RIFAMPICIN and various plant metabolites, such as hyperforin, guggulipid, colupulone, and ISOFLAVONES. |
|---|---|
| altLabel |
Steroid X Receptor
SXR Receptor
Nuclear Receptor Subfamily 1, Group I, Member 2
NR1I2
Steroid and Xenobiotic Receptor
|
| prefLabel | Pregnane X Receptor
|
| Machine permutation | 2019; PREGNANE X RECEPTOR was indexed under RECEPTORS, STEROID 2007-2018; and under RECEPTORS, CYTOPLASMIC AND NUCLEAR 1998-2006
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| HN | 2019 (1998)
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| Mapped from | |
| type | |
| tui |
T116
T192
|
| TERMUI |
T000938871
T000940016
T000940017
T000938872
T000938869
T000938870
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| TH |
NLM (2000)
NLM (2019)
NLM (2006)
NLM (1998)
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| MMR | 20190101
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| notation | D000077297
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| Semantic type UMLS property | |
| Inverse of AQ |
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|
| DX | 20190101
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| cui | C0671771
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| DC | 1
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| MN |
D12.776.930.778.175
D12.776.826.750.075
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| AQL | AD AG AI AN BI BL CH CL DE DF GE HI IM IP ME PH RE TU UL
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| Inverse of RB | 0
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| MDA | 20180109
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |