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Medical Subject Headings
Last uploaded:
March 22, 2026
| Id | http://purl.bioontology.org/ontology/MESH/D000074884
http://purl.bioontology.org/ontology/MESH/D000074884
|
|---|---|
| Preferred Name | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein |
| Definitions |
A caspase-like cysteine endopeptidase that also exhibits ubiquitin ligase activity. It contains an N-terminal DEATH DOMAIN, two IMMUNOGLOBULIN-LIKE DOMAINS, and localizes to the perinuclear region of MONOCYTES, where it functions in activation of NF-KAPPA B; it also binds to and activates TRAF6. Chromosomal translocations involving the MALT1 and BIRC2 genes are associated with MALT LYMPHOMA, and mutations in the MALT1 gene are associated with Type 12 IMMUNODEFICIENCY SYNDROMES.
|
| Synonyms |
Mucosa Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
Paracaspase
MALT1 Paracaspase
MALT 1 Protein
Paracaspase, MALT1
MALT-1 Protein
MALT1 Protein
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A caspase-like cysteine endopeptidase that also exhibits ubiquitin ligase activity. It contains an N-terminal DEATH DOMAIN, two IMMUNOGLOBULIN-LIKE DOMAINS, and localizes to the perinuclear region of MONOCYTES, where it functions in activation of NF-KAPPA B; it also binds to and activates TRAF6. Chromosomal translocations involving the MALT1 and BIRC2 genes are associated with MALT LYMPHOMA, and mutations in the MALT1 gene are associated with Type 12 IMMUNODEFICIENCY SYNDROMES. |
|---|---|
| altLabel |
Mucosa Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
Paracaspase
MALT1 Paracaspase
MALT 1 Protein
Paracaspase, MALT1
MALT-1 Protein
MALT1 Protein
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| prefLabel | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
|
| Machine permutation | 2018
|
| HN | 2018
|
| Mapped from | |
| type | |
| tui |
T116
T123
|
| TERMUI |
T000919270
T000919264
T000919269
T000919266
T000919267
|
| TH | NLM (2018)
|
| MMR | 20180101
|
| notation | D000074884
|
| Semantic type UMLS property | |
| Inverse of AQ |
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|
| DX | 20180101
|
| cui | C1881915
|
| DC | 1
|
| MN |
D08.811.277.656.262.500.126.775
D08.811.464.938.750.233
D08.811.277.656.300.200.126.775
|
| AQL | AD AE AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
|
| Inverse of RB | EC 3.4.22.-
|
| MDA | 20170317
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |