Medical Subject Headings

Last uploaded: March 22, 2026
Id http://purl.bioontology.org/ontology/MESH/D000071162
http://purl.bioontology.org/ontology/MESH/D000071162
Preferred Name

Trefoil Factors

Definitions
A family of small peptides expressed primarily by MUCOUS MEMBRANE EPITHELIAL CELLS in vertebrates. Their structure is highly conserved and is defined by a three-leaved (trefoil) domain of 42 or 43 amino acids; it includes six cysteines that create the trefoil structure through disulfide bridges. Trefoil peptides may form dimers with each other, or associate with MUCINS and other factors. They are important for maintaining epithelial integrity and for protection from noxious agents.
Synonyms
TFF Peptide
TFF Peptides
Trefoil Proteins
Peptide, TFF
Trefoil Factor Family Proteins
Trefoil Factor Family Peptides
Factor, Trefoil
Peptide, Trefoil
Trefoil Peptides
Trefoil Peptide
Protein, Trefoil
Trefoil Protein
Trefoil Factor
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Type http://www.w3.org/2002/07/owl#Class
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