Medical Subject Headings

Last uploaded: March 22, 2026

Id	http://purl.bioontology.org/ontology/MESH/C074907 http://purl.bioontology.org/ontology/MESH/C074907
Preferred Name	2-carboxy-4-(carboxymethyl)-5,7-dichloro-1,2,3,4-tetrahydroquinoline
Synonyms	trans-2-carboxy-4-(carboxymethyl)5,7-dichloro-1,2,3,4-tetrahydroquinoline CCM-dichloro-THQ
Type	http://www.w3.org/2002/07/owl#Class

altLabel	trans-2-carboxy-4-(carboxymethyl)5,7-dichloro-1,2,3,4-tetrahydroquinoline CCM-dichloro-THQ
prefLabel	2-carboxy-4-(carboxymethyl)-5,7-dichloro-1,2,3,4-tetrahydroquinoline
Scope Statement	structure given in first source; high potency towards antagonism of glycine site of NMDA (N-methyl-D-aspartate) receptor; (trans)-isomer has 100 times more affinity towards receptor than (cis)-isomer; RN refers to the (trans)-isomer
type	http://www.w3.org/2002/07/owl#Class
tui	T109
HM	D011804
SC	1
TERMUI	T232052 T232051 T232053
TH	NLM (1992)
SRC	J Med Chem 1992 May 29;35(11):1942-53
MMR	20010510
notation	C074907
Semantic type UMLS property	http://purl.bioontology.org/ontology/STY/T109
cui	C0651902 C0651901
MeSH Frequency	1
DSC	19920706
Inverse of RB	132691-83-9
Mapped to	http://purl.bioontology.org/ontology/MESH/D011804
MDA	19920706

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