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MedlinePlus Health Topics
Last uploaded:
March 22, 2026
| Id | http://purl.bioontology.org/ontology/MEDLINEPLUS/C1428829
http://purl.bioontology.org/ontology/MEDLINEPLUS/C1428829
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|---|---|
| Preferred Name | KN motif and ankyrin repeat domains 2 |
| Definitions |
The KANK2 gene provides instructions for making a protein called SRC-interacting protein (SIP). SIP regulates proteins called steroid receptor coactivators (SRCs), which play critical roles in turning on (activating) certain genes. Within cells, SIP attaches (binds) to SRCs in the fluid surrounding the nucleus (the cytoplasm). By holding SRCs in the cytoplasm, SIP prevents these proteins from entering the nucleus to activate genes. In this way, SIP helps to control gene activity.~SIP is found in many organs and tissues, including the skin and kidneys. Little is known about its specific roles in various parts of the body.
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| Synonyms |
SRC-1 interacting protein
ANKRD25
PPKWH
KANK2
matrix-remodelling associated 3
MXRA3
ankyrin repeat domain 25
SIP
KIAA1518
matrix-remodeling-associated protein 3
SRC-interacting protein
SRC1-interacting protein
ankyrin repeat domain-containing protein 25
kidney ankyrin repeat-containing protein 2
SRC-1-interacting protein
See more
See less
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The KANK2 gene provides instructions for making a protein called SRC-interacting protein (SIP). SIP regulates proteins called steroid receptor coactivators (SRCs), which play critical roles in turning on (activating) certain genes. Within cells, SIP attaches (binds) to SRCs in the fluid surrounding the nucleus (the cytoplasm). By holding SRCs in the cytoplasm, SIP prevents these proteins from entering the nucleus to activate genes. In this way, SIP helps to control gene activity.~SIP is found in many organs and tissues, including the skin and kidneys. Little is known about its specific roles in various parts of the body. |
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| altLabel |
SRC-1 interacting protein
ANKRD25
PPKWH
KANK2
matrix-remodelling associated 3
MXRA3
ankyrin repeat domain 25
SIP
KIAA1518
matrix-remodeling-associated protein 3
SRC-interacting protein
SRC1-interacting protein
ankyrin repeat domain-containing protein 25
kidney ankyrin repeat-containing protein 2
SRC-1-interacting protein
See more
See less
|
| prefLabel | KN motif and ankyrin repeat domains 2
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| DB XR ID | NCBI Gene:25959~OMIM:614610
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| Has associated condition | |
| type | |
| tui | T028
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| notation | C1428829
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| Semantic type UMLS property | |
| cui | C1428829
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