MedlinePlus Health Topics

Last uploaded: March 22, 2026
Id http://purl.bioontology.org/ontology/MEDLINEPLUS/C1420009
http://purl.bioontology.org/ontology/MEDLINEPLUS/C1420009
Preferred Name

sarcoglycan gamma

Definitions
The SGCG gene provides instructions for making the gamma component (subunit) of a group of proteins called the sarcoglycan protein complex. The sarcoglycan protein complex is located in the membrane surrounding muscle cells. It helps maintain the structure of muscle tissue by attaching (binding) to and stabilizing the dystrophin complex, which is made up of proteins called dystrophins and dystroglycans. The large dystrophin complex strengthens muscle fibers and protects them from injury as muscles tense (contract) and relax. It acts as an anchor, connecting each muscle cell's structural framework (cytoskeleton) with the lattice of proteins and other molecules outside the cell (extracellular matrix).
Synonyms
TYPE
SGCG_HUMAN
LGMD2C
DAGA4
gamma-sarcoglycan
DMDA
35DAG
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
A4
gamma-SG
DMDA1
SG-gamma
MAM
MGC130048
SCG3
gamma sarcoglycan
35kD dystrophin-associated glycoprotein
35 kDa dystrophin-associated glycoprotein
SCARMD2
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Type http://www.w3.org/2002/07/owl#Class
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