MedlinePlus Health Topics

Last uploaded: March 22, 2026
Id http://purl.bioontology.org/ontology/MEDLINEPLUS/C1420006
http://purl.bioontology.org/ontology/MEDLINEPLUS/C1420006
Preferred Name

sarcoglycan beta

Definitions
The SGCB gene provides instructions for making the beta component (subunit) of a group of proteins called the sarcoglycan protein complex. The sarcoglycan protein complex is located in the membrane surrounding muscle cells. It helps maintain the structure of muscle tissue by attaching (binding) to and stabilizing the dystrophin complex, which is made up of proteins called dystrophins and dystroglycans. The large dystrophin complex strengthens muscle fibers and protects them from injury as muscles tense (contract) and relax. It acts as an anchor, connecting each muscle cell's structural framework (cytoskeleton) with the lattice of proteins and other molecules outside the cell (extracellular matrix).
Synonyms
SGCB
SGC
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
beta-sarcoglycan
A3b
SG-beta
43DAG
43 kDa dystrophin-associated glycoprotein
SGCB_HUMAN
LGMD2E
beta-SG
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Type http://www.w3.org/2002/07/owl#Class
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