MedlinePlus Health Topics

Last uploaded: March 22, 2026
Id http://purl.bioontology.org/ontology/MEDLINEPLUS/C1420005
http://purl.bioontology.org/ontology/MEDLINEPLUS/C1420005
Preferred Name

sarcoglycan alpha

Definitions
The SGCA gene provides instructions for making the alpha component (subunit) of a group of proteins called the sarcoglycan protein complex. The sarcoglycan protein complex is located in the membrane surrounding muscle cells. It helps maintain the structure of muscle tissue by attaching (binding) to and stabilizing the dystrophin complex, which is made up of proteins called dystrophins and dystroglycans. The large dystrophin complex strengthens muscle fibers and protects them from injury as muscles tense (contract) and relax. It acts as an anchor, connecting each muscle cell's structural framework (cytoskeleton) with the lattice of proteins and other molecules outside the cell (extracellular matrix).
Synonyms
DAG2
LGMD2D
ADL
SGCA
SCARMD1
alpha-sarcoglycan
50 kDa dystrophin-associated glycoprotein
50kD DAG
50-DAG
50DAG
DMDA2
SGCA_HUMAN
SG-alpha
adhalin
alpha-SG
dystroglycan-2
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
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Type http://www.w3.org/2002/07/owl#Class
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