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MedlinePlus Health Topics
Last uploaded:
March 22, 2026
| Id | http://purl.bioontology.org/ontology/MEDLINEPLUS/C1420005
http://purl.bioontology.org/ontology/MEDLINEPLUS/C1420005
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|---|---|
| Preferred Name | sarcoglycan alpha |
| Definitions |
The SGCA gene provides instructions for making the alpha component (subunit) of a group of proteins called the sarcoglycan protein complex. The sarcoglycan protein complex is located in the membrane surrounding muscle cells. It helps maintain the structure of muscle tissue by attaching (binding) to and stabilizing the dystrophin complex, which is made up of proteins called dystrophins and dystroglycans. The large dystrophin complex strengthens muscle fibers and protects them from injury as muscles tense (contract) and relax. It acts as an anchor, connecting each muscle cell's structural framework (cytoskeleton) with the lattice of proteins and other molecules outside the cell (extracellular matrix).
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| Synonyms |
DAG2
LGMD2D
ADL
SGCA
SCARMD1
alpha-sarcoglycan
50 kDa dystrophin-associated glycoprotein
50kD DAG
50-DAG
50DAG
DMDA2
SGCA_HUMAN
SG-alpha
adhalin
alpha-SG
dystroglycan-2
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
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|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The SGCA gene provides instructions for making the alpha component (subunit) of a group of proteins called the sarcoglycan protein complex. The sarcoglycan protein complex is located in the membrane surrounding muscle cells. It helps maintain the structure of muscle tissue by attaching (binding) to and stabilizing the dystrophin complex, which is made up of proteins called dystrophins and dystroglycans. The large dystrophin complex strengthens muscle fibers and protects them from injury as muscles tense (contract) and relax. It acts as an anchor, connecting each muscle cell's structural framework (cytoskeleton) with the lattice of proteins and other molecules outside the cell (extracellular matrix). |
|---|---|
| altLabel |
DAG2
LGMD2D
ADL
SGCA
SCARMD1
alpha-sarcoglycan
50 kDa dystrophin-associated glycoprotein
50kD DAG
50-DAG
50DAG
DMDA2
SGCA_HUMAN
SG-alpha
adhalin
alpha-SG
dystroglycan-2
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
See more
See less
|
| prefLabel | sarcoglycan alpha
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| DB XR ID | NCBI Gene:6442~OMIM:600119
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| Has associated condition | |
| type | |
| tui | T028
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| notation | C1420005
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| Semantic type UMLS property | |
| cui | C1420005
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