The PRNP gene provides instructions for making a protein called prion protein (PrP), which is active in the brain and several other tissues. Although the precise function of this protein is unknown, researchers have proposed that it play a role in several important processes. These include the transport of copper into cells and the protection of brain cells (neurons) from injury (neuroprotection). Studies have also suggested that PrP plays a role in the formation of synapses, which are the junctions between neurons where cell-to-cell communication occurs.~Different forms of PrP have been identified. The normal version is often designated PrP<html:sup>C</html:sup> to distinguish it from abnormal forms of the protein, which are generally designated PrP<html:sup>Sc</html:sup>.