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Breast Tissue Cell Lines Ontology
Last uploaded:
July 29, 2010
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Id | http://purl.obolibrary.org/obo/MCBCC_0000038#INS
http://purl.obolibrary.org/obo/MCBCC_0000038#INS
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Preferred Name | INS |
Type | http://www.w3.org/2002/07/owl#Class |
All Properties
prefLabel | INS
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isDefinedBy | After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region.
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prefixIRI | MCBCC_0000038:INS
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subClassOf | |
type |
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